The medial prefrontal cortex (mPFC) drives cocaine‐seeking behaviour in rodent models of
cocaine use disorder. Parvalbumin (PV)‐containing GABAergic interneurons powerfully …

Parvalbumin (PV)-positive cells are GABAergic fast-spiking interneurons that modulate the
activity of pyramidal neurons in the medial prefrontal cortex (mPFC) and their output to brain …

Substance use disorder is a complex disease created in part by maladaptive learning and
memory mechanisms following repeated drug use. Exposure to drug‐associated stimuli …

Addiction involves drug-induced neuroplasticity in the circuitry of motivated behavior, which
includes the medial forebrain bundle and the lateral hypothalamic area. Emerging at the …

The medial prefrontal cortex (mPFC) is a major contributor to relapse to cocaine in humans
and to reinstatement behavior in rodent models of cocaine use disorder. Output from the …

Pyramidal neurons in the medial prefrontal cortex (mPFC) critically contribute to cocaine-
seeking behavior in humans and rodents. Activity of these neurons is significantly modulated …

We previously reported that perineuronal nets (PNNs) are required for cocaine-associated
memories. Perineuronal nets are extracellular matrix that primarily surrounds parvalbumin …

Cocaine treatment paired with environmental cues establishes a conditioned place
preference (CPP) for that environment. After expression of this preference, rats show …

Rationale The probability of structural remodeling in brain circuits may be modulated by
molecules of perineuronal nets (PNNs) that restrict neuronal plasticity to stabilize circuits …

Recent studies suggest that the ventral medial prefrontal cortex (vmPFC) encodes both
operant drug self-administration and extinction memories. Here, we examined whether …