Alopecia areata: autoreactive T cells are variably enriched in scalp lesions relative to peripheral blood

RS Kalish, KL Johnson, MK Hordinsky - Archives of dermatology, 1992 - jamanetwork.com
• Background and Design.—Alopecia areata is a condition characterized by hair loss in
association with perifollicular infiltration of T cells and antigen-presenting cells. Autoreactive …

[引用][C] In situ demonstration of T cells in alopecia areata

CH Perret, EB Bröcker, L Wiesner-Menzel… - Archives of …, 1982 - Springer
The etiology of alopecia areata is unknown. Some clinical features, such as the association
with autoimmune disorders [16] suggest an autoimmune pathogenesis. The immunologic …

Alopecia areata but not androgenetic alopecia is characterized by a restricted and oligoclonal T‐cell receptor‐repertoire among infiltrating lymphocytes

D Dressel, CH Brütt, B Manfras… - Journal of cutaneous …, 1997 - Wiley Online Library
Although the etiology of alopecia areata is still unknown, evidence has accumulated to
support an autoimmune pathogenesis for this disease. To evaluate the role of T cells in …

Immunohistochemical analysis of T-cell subsets in the peribulbar and intrabulbar infiltrates of alopecia areata.

C Perret, L Wiesner-Menzel… - Acta dermato …, 1984 - europepmc.org
In 11 patients with untreated alopecia areata in the progressive stage of the disease, an in
situ analysis of the inflammatory infiltrate of the hair bulbs was performed by means of …

Increased ratio of helper to suppressor T cells in alopecia areata

BBJ Majewski, MS Koh, DR Taylor… - British Journal of …, 1984 - Wiley Online Library
We studied lymphocyte subsets in the blood of twenty‐four patients with alopecia areata of
various degrees of severity. There was an increase in the ratio of helper to suppressor cells …

Lesional alopecia areata T lymphocytes downregulate epithelial cell proliferation

C Thein, P Strange, ER Hansen… - Archives of dermatological …, 1997 - Springer
Alopecia areata is characterized by peribulbar infiltration by activated T cells. The function of
these T cells in the pathogenesis is unknown. To elucidate the potential role of lesional T …

Alopecia areata is a T-lymphocyte mediated autoimmune disease: lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice

A Gilhar, R Shalaginov, B Assy, S Serafimovich… - Journal of Investigative …, 1999 - Elsevier
Much evidence suggests that alopecia areata is a tissue restricted autoimmune disease.
Alopecia areata responds to immunosuppressive agents, and is associated with other tissue …

Increased HLA‐DR+ T‐lymphocyte population in peripheral blood of alopecia areata

R Imai, J Miura, K Takamori… - Clinical and experimental …, 1991 - Wiley Online Library
The populations of activated T‐cell subsets [HLA‐DR+‐Leu 4+ cells, interleukin 2 receptor
positive (IL‐2R+)‐Leu 4+ cells] in the peripheral blood of patients with alopecia areata (AA) …

In situ lymphocyte subsets in alopecia areata before and during treatment with a contact allergen

O Baadsgaard, R LLNDSKOV… - Clinical and …, 1987 - academic.oup.com
In situ lymphocyte subsets in 12 patients with patchy alopecia areata or alopecia universalis
were estimated using monoclonal antibodies and immunoperoxidase technique. The …

T cell subpopulaions in alopecia areata

N Todes-Taylor, R Turner, GS Wood, PT Stratte… - Journal of the American …, 1984 - Elsevier
Alopecia areata remains a disease of unknown cause and unsatisfactory treatment.
Histologically it is characterized by a lymphocytic infiltrate that surrounds the lower half of the …