The Transient Receptor Potential Melastatin 4 (TRPM4) is a transmembrane N-glycosylated
ion channel that belongs to the large family of TRP proteins. It has an equal permeability to …

Highlights•Mutations in the TRPM4 gene are associated with dysfunctions in the cardiac
conduction system.•At the molecular level mutations in TRPM4 lead to gain-of-channel …

Transient receptor potential melastatin member 4 (TRPM4), a non-selective cation channel,
mediates cell membrane depolarization in immune response, insulin secretion, neurological …

Progressive cardiac conduction disease (PCCD) is a relatively common condition in young
and elderly populations, related to rare mutations in several genes, including SCN5A …

Transient receptor potential melastatin member 4 (TRPM4) encodes a Ca2+-activated, non-
selective cation channel that is functionally expressed in several tissues, including the heart …

The transient receptor potential channel (TRP) family comprises at least 28 genes in the
human genome. These channels are widely expressed in many different tissues, including …

A gain-of-function mutation in the Ca 2+-activated transient receptor potential melastatin
member 4 (TRPM4 A432T) is linked to life-threatening cardiac conduction disturbance, but …

Background Transient receptor potential melastatin member 4 (TRPM 4) is a nonselective
cation channel. TRPM 4 mutations have been linked to cardiac conduction disease and …

Very recently, mutations in the TRPM4 gene have been identified in four pedigrees as the
cause of an autosomal dominant form of cardiac conduction disease. To determine the role …

The transient receptor potential melastatin 4 (TRPM4) channel is a non-selective cation
channel that activates in response to increased intracellular Ca2+ levels but does not allow …