ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut
Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell
responses, but the mechanisms controlling these distinct outcomes remain poorly …
responses, but the mechanisms controlling these distinct outcomes remain poorly …
RORγt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota
S Sawa, M Lochner, N Satoh-Takayama… - Nature …, 2011 - nature.com
Lymphoid cells that express the nuclear hormone receptor RORγt are involved in
containment of the large intestinal microbiota and defense against pathogens through the …
containment of the large intestinal microbiota and defense against pathogens through the …
A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation
The mutualistic relationship of gut-resident microbiota and the host immune system
promotes homeostasis that ensures maintenance of the microbial community and of a …
promotes homeostasis that ensures maintenance of the microbial community and of a …
[HTML][HTML] Novel antigen-presenting cell imparts Treg-dependent tolerance to gut microbiota
B Akagbosu, Z Tayyebi, G Shibu, YA Paucar Iza… - Nature, 2022 - nature.com
Establishing and maintaining tolerance to self-antigens or innocuous foreign antigens is vital
for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells …
for the preservation of organismal health. Within the thymus, medullary thymic epithelial cells …
ZBTB46 defines and regulates ILC3s that protect the intestine
RORγt is a lineage-specifying transcription factor that is expressed by immune cells that are
enriched in the gastrointestinal tract and promote immunity, inflammation and tissue …
enriched in the gastrointestinal tract and promote immunity, inflammation and tissue …
Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2
Abstract Interleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic
inflammation in the gastrointestinal tract,,–. The protective effects of IL-2 involve the …
inflammation in the gastrointestinal tract,,–. The protective effects of IL-2 involve the …
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
Innate lymphoid cells (ILCs) are a recently characterized family of immune cells that have
critical roles in cytokine-mediated regulation of intestinal epithelial cell barrier integrity …
critical roles in cytokine-mediated regulation of intestinal epithelial cell barrier integrity …
Complementarity and redundancy of IL-22-producing innate lymphoid cells
Intestinal T cells and group 3 innate lymphoid cells (ILC3 cells) control the composition of
the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either …
the microbiota and gut immune responses. Within the gut, ILC3 subsets coexist that either …
c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont
Both microbial and host genetic factors contribute to the pathogenesis of autoimmune
diseases,,,. There is accumulating evidence that microbial species that potentiate chronic …
diseases,,,. There is accumulating evidence that microbial species that potentiate chronic …
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota
Peripheral mechanisms preventing autoimmunity and maintaining tolerance to commensal
microbiota involve CD4+ Foxp3+ regulatory T (Treg) cells, generated in the thymus or …
microbiota involve CD4+ Foxp3+ regulatory T (Treg) cells, generated in the thymus or …