Nuclear localization of nucleocapsid-like particles and HCV core protein in hepatocytes of a chronically HCV-infected patient
V Falcón, N Acosta-Rivero, G Chinea… - Biochemical and …, 2003 - Elsevier
Little is known about the life cycle of hepatitis C virus. Determination of the subcellular
localization of HCV proteins may contribute to our understanding of the in vivo functions of …
localization of HCV proteins may contribute to our understanding of the in vivo functions of …
Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
G Barba, F Harper, T Harada… - Proceedings of the …, 1997 - National Acad Sciences
There is now abundant evidence to substantiate an important role of hepatitis C virus (HCV)
core protein in cellular gene expression as well as in the viral cycle. Thus the subcellular …
core protein in cellular gene expression as well as in the viral cycle. Thus the subcellular …
Nuclear localization signals in the core protein of hepatitis C virus
The core protein of the hepatitis C virus is derived from the N-terminal 191 amino acids of
the viral polyprotein by proteolytic cleavage. In the current study, subcellular localizations of …
the viral polyprotein by proteolytic cleavage. In the current study, subcellular localizations of …
Molecular determinants for subcellular localization of hepatitis C virus core protein
R Suzuki, S Sakamoto, T Tsutsumi, A Rikimaru… - Journal of …, 2005 - Am Soc Microbiol
Hepatitis C virus (HCV) core protein is a putative nucleocapsid protein with a number of
regulatory functions. In tissue culture cells, HCV core protein is mainly located at the …
regulatory functions. In tissue culture cells, HCV core protein is mainly located at the …
The N-terminal half of the core protein of hepatitis C virus is sufficient for nucleocapsid formation
N Majeau, V Gagne, A Boivin… - Journal of general …, 2004 - microbiologyresearch.org
The core (C) protein of hepatitis C virus (HCV) appears to be a multifunctional protein that is
involved in many viral and cellular processes. Although its effects on host cells have been …
involved in many viral and cellular processes. Although its effects on host cells have been …
Identification of basic amino acids at the N-terminal end of the core protein that are crucial for hepatitis C virus infectivity
K Alsaleh, PY Delavalle, A Pillez, G Duverlie… - Journal of …, 2010 - Am Soc Microbiol
ABSTRACT A major function of the hepatitis C virus (HCV) core protein is the interaction with
genomic RNA to form the nucleocapsid, an essential component of the virus particle …
genomic RNA to form the nucleocapsid, an essential component of the virus particle …
Hepatitis C virus core protein promotes immortalization of primary human hepatocytes
Hepatitis C virus (HCV) core protein has many intriguing properties as a viral factor and is
implicated in cell growth regulation. In this study, the cell growth regulation potential of HCV …
implicated in cell growth regulation. In this study, the cell growth regulation potential of HCV …
Properties of the hepatitis C virus core protein: a structural protein that modulates cellular processes
McLauchlan - Journal of viral hepatitis, 2000 - Wiley Online Library
The core protein of hepatitis C virus (HCV) is believed to form the capsid shell of virus
particles. Maturation of the protein is achieved through cleavage by host cell proteases to …
particles. Maturation of the protein is achieved through cleavage by host cell proteases to …
Assembly of truncated HCV core antigen into virus-like particles in Escherichia coli
LJ Lorenzo, S Dueñas-Carrera, V Falcón… - Biochemical and …, 2001 - Elsevier
Core protein is one of the most conserved and immunogenic of the hepatitis C virus proteins.
Several pieces of experimental evidence suggest its ability for formation of virus like …
Several pieces of experimental evidence suggest its ability for formation of virus like …
Nonenveloped nucleocapsids of hepatitis C virus in the serum of infected patients
P Maillard, K Krawczynski, J Nitkiewicz… - Journal of …, 2001 - Am Soc Microbiol
One of the characteristics of hepatitis C virus (HCV) is the high incidence of persistent
infection. HCV core protein, in addition to forming the viral nucleocapsid, has multiple …
infection. HCV core protein, in addition to forming the viral nucleocapsid, has multiple …