Background Chronic obstructive pulmonary disease (COPD) is thought to result from an
accelerated decline in forced expiratory volume in 1 second (FEV1) over time. Yet it is …

Rationale: Chronic obstructive pulmonary disease (COPD) can develop not only through a
lung function trajectory dominated by an accelerated decline of FEV1 from normal maximally …

Background A key feature of chronic obstructive pulmonary disease (COPD) is an
accelerated rate of decline in forced expiratory volume in 1 second (FEV1), but data on the …

Rationale: Chronic obstructive pulmonary disease (COPD) is thought to result in rapid and
progressive loss of lung function usually expressed as mean values for whole cohorts …

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow
limitation that is not fully reversible (1). Like many other major chronic diseases the burden …

Rationale: Although the rate of annual decline in FEV1 is one of the most important outcome
measures in chronic obstructive pulmonary disease (COPD), little is known about …

Early-Life Origins of Chronic Obstructive Pulmonary Disease | NEJM Skip to main content
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Forced expiratory volume in 1 second (FEV1) declines normally with aging by approximately
30 mL/yr, but in susceptible smokers, the decline is greater (about 60 mL/yr), resulting in the …

Rationale: Low maximally attained lung function increases the risk of chronic obstructive
pulmonary disease irrespective of the subsequent rate of lung function decline. Objectives …

The natural history of COPD is complex, and the disease is best understood as a syndrome
resulting from numerous interacting factors throughout the life cycle with smoking being the …