Nanowired human cardiac organoid transplantation enables highly efficient and effective recovery of infarcted hearts

Y Tan, RC Coyle, RW Barrs, SE Silver, M Li… - Science …, 2023 - science.org
Human cardiac organoids hold remarkable potential for cardiovascular disease modeling
and human pluripotent stem cell–derived cardiomyocyte (hPSC-CM) transplantation. Here …

Nanowires and electrical stimulation synergistically improve functions of hiPSC cardiac spheroids

DJ Richards, Y Tan, R Coyle, Y Li, R Xu, N Yeung… - Nano …, 2016 - ACS Publications
The advancement of human induced pluripotent stem-cell-derived cardiomyocyte (hiPSC-
CM) technology has shown promising potential to provide a patient-specific, regenerative …

[HTML][HTML] Human pluripotent stem cell-derived cardiac tissue-like constructs for repairing the infarcted myocardium

J Li, I Minami, M Shiozaki, L Yu, S Yajima, S Miyagawa… - Stem Cell Reports, 2017 - cell.com
High-purity cardiomyocytes (CMs) derived from human induced pluripotent stem cells
(hiPSCs) are promising for drug development and myocardial regeneration. However, most …

Functional engineered human cardiac patches prepared from nature's platform improve heart function after acute myocardial infarction

Q Wang, H Yang, A Bai, W Jiang, X Li, X Wang, Y Mao… - Biomaterials, 2016 - Elsevier
With the advent of induced pluripotent stem cells and directed differentiation techniques, it is
now feasible to derive individual-specific cardiac cells for human heart tissue engineering …

[HTML][HTML] Engineering the heart: evaluation of conductive nanomaterials for improving implant integration and cardiac function

J Zhou, J Chen, H Sun, X Qiu, Y Mou, Z Liu, Y Zhao… - Scientific reports, 2014 - nature.com
Recently, carbon nanotubes together with other types of conductive materials have been
used to enhance the viability and function of cardiomyocytes in vitro. Here we demonstrated …

Silicon nanowire-induced maturation of cardiomyocytes derived from human induced pluripotent stem cells

Y Tan, D Richards, R Xu, S Stewart-Clark, SK Mani… - Nano …, 2015 - ACS Publications
The current inability to derive mature cardiomyocytes from human pluripotent stem cells has
been the limiting step for transitioning this powerful technology into clinical therapies. To …

Challenges and opportunities for the next generation of cardiovascular tissue engineering

S Cho, DE Discher, KW Leong, G Vunjak-Novakovic… - Nature …, 2022 - nature.com
Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …

[HTML][HTML] Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells

M Ding, H Andersson, S Martinsson, A Sabirsh… - Scientific reports, 2020 - nature.com
Cardiac progenitor cells (CPCs), capable of differentiating into multiple cardiac cell types
including cardiomyocytes (CMs), endothelial cells, and smooth muscle cells, are promising …

Transplanted microvessels improve pluripotent stem cell–derived cardiomyocyte engraftment and cardiac function after infarction in rats

X Sun, J Wu, B Qiang, R Romagnuolo… - Science translational …, 2020 - science.org
Human induced pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) offer an
unprecedented opportunity to remuscularize infarcted human hearts. However, studies have …

[HTML][HTML] Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells

L Ye, YH Chang, Q Xiong, P Zhang, L Zhang… - Cell stem cell, 2014 - cell.com
Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following
injury, but preclinical studies in large animal models are required to determine optimal cell …