Randomized controlled trials (RCTs) represent the gold standard for evidence generation
across all areas of medicine and especially in the oncology field, as they allow unbiased …

Current medical training often does not include the formal study of trial design, forcing
clinicians to acquire this knowledge independently. This article reviews the foundational …

Real‐world evidence includes all health‐related information, such as electronic health
records, insurance claims, pharmacy records and wearables that are obtained outside of …

The growing diffusion of digitalisation and informatics has promoted the creation and
analysis of large databases able to provide solid information. Analyses of “big data” …

Design and execution of clinical trials use definitions and criteria to permit a homogeneous
study development avoiding heterogeneous decisions by investigators at different sites …

The design of prospective trials in hepatocellular carcinoma is a true challenge because the
underlying condition of the liver, upon drug exposure, could interact with the specific course …

Despite the fact that the hepatocellular carcinoma (HCC) represents a major health problem,
very few interventions are available for this disease, and only sorafenib is approved for the …

Introduction: Clinical trials in hepatocellular carcinoma (HCC) exhibit a high degree of
heterogeneity. These heterogeneities may lead to unexpected results among clinical trials …

Objective Hepatocellular carcinoma (HCC) is the third leading cause of cancer death
worldwide. We conducted network meta-regression within a Bayesian framework to …

The design of clinical trials in hepatocellular carcinoma (HCC) is complex because many
patients have concurrent liver disease, which can confound the assessment of clinical …