DNA end resection has a key role in double-strand break repair and DNA replication.
Defective DNA end resection can cause malfunctions in DNA repair and replication, leading …

End resection of DNA—which is essential for the repair of DNA double‐strand breaks
(DSBs) by homologous recombination—relies first on the partnership between MRE11 …

DNA double-strand breaks (DSBs), which arise following exposure to a number of
endogenous and exogenous agents, can be repaired by either the homologous …

The repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) is
initiated by nucleolytic degradation of the 5′-terminated strands in a process termed end …

DNA double-strand break repair by homologous recombination entails the resection of DNA
ends to reveal ssDNA tails, which are used to invade a homologous DNA template. CtIP and …

Repair of dsDNA breaks requires processing to produce 3′-terminated ssDNA. We
biochemically reconstituted DNA end resection using purified human proteins: Bloom …

DNA double-strand breaks (DSBs) in cells can undergo nucleolytic degradation to generate
long 3′ single-stranded DNA tails. This process is termed DNA end resection, and its …

To repair a DNA double-strand break by homologous recombination, 5′-terminated DNA
strands must first be resected to reveal 3′-overhangs. This process is initiated by a short …

Homologous recombination (HR) is initiated by DNA end resection, a process in which
stretches of single-strand DNA (ssDNA) are generated and used for homology search …

Double-strand breaks (DSBs) are deleterious DNA lesions and if left unrepaired result in
severe genomic instability. Cells use two main pathways to repair DSBs: homologous …