[HTML][HTML] The potential roles of gossypol as anticancer agent: advances and future directions
D Paunovic, J Rajkovic, R Novakovic… - Chinese Medicine, 2023 - Springer
Gossypol, a polyphenolic aldehyde derived from cottonseed plants, has seen a
transformation in its pharmaceutical application from a male contraceptive to a candidate for …
transformation in its pharmaceutical application from a male contraceptive to a candidate for …
[HTML][HTML] Gossypol and its natural derivatives: multitargeted phytochemicals as potential drug candidates for oncologic diseases
Despite the vast amounts of research and remarkable discoveries that have been made in
recent decades, cancer remains a leading cause of death and a major public health concern …
recent decades, cancer remains a leading cause of death and a major public health concern …
Structure, properties of gossypol and its derivatives—from physiological activities to drug discovery and drug design
Y Liu, L Wang, L Zhao, Y Zhang - Natural product reports, 2022 - pubs.rsc.org
Covering up to 2022 Gossypol is a polyphenolic compound isolated from cottonseed. There
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …
Natural product gossypol and its derivatives in precision cancer medicine
Gossypol, a natural product extracted from the seed, roots, and stem of cotton, was initially
used as a male contraceptive but was subsequently investigated as a novel antitumor agent …
used as a male contraceptive but was subsequently investigated as a novel antitumor agent …
Cytotoxic effect of gossypol on colon carcinoma cells
X Wang, J Wang, SCH Wong, LSN Chow, JM Nicholls… - Life Sciences, 2000 - Elsevier
Gossypol, a male contraceptive drug extracted from cottonseeds, has been found to have
antiproliferative activity on tumour cells and is thought to be a potential anticancer drug. The …
antiproliferative activity on tumour cells and is thought to be a potential anticancer drug. The …
Recent advances in gossypol derivatives and analogs: a chemistry and biology view
Y Lu, J Li, CE Dong, J Huang, HB Zhou… - Future Medicinal …, 2017 - Taylor & Francis
Gossypol as a natural occurring polyphenol has been studied in a wide range of therapeutic
contexts for a long time. The chemical modifications on gossypol were limited due to the …
contexts for a long time. The chemical modifications on gossypol were limited due to the …
Gossypol inhibits phosphorylation of Bcl-2 in human leukemia HL-60 cells
L Huang, J Hu, W Tao, Y Li, G Li, P Xie, X Liu… - European journal of …, 2010 - Elsevier
Gossypol is an attractive therapeutic anti-tumor agent as an apoptosis inducer and is being
evaluated in preclinical tests. However, the molecular mechanisms underlying apoptosis …
evaluated in preclinical tests. However, the molecular mechanisms underlying apoptosis …
Therapeutic potential of gossypol: an overview
H Keshmiri-Neghab, B Goliaei - Pharmaceutical Biology, 2014 - Taylor & Francis
Context: Polyphenols are naturally occurring compounds found in fruits, vegetables, cereals,
and beverages. Polyphenols occupy a unique place in biological science for their …
and beverages. Polyphenols occupy a unique place in biological science for their …
Reaction chemistry of gossypol and its derivatives
JA Kenar - Journal of the American Oil Chemists' Society, 2006 - Wiley Online Library
Gossypol, a complex polyphenolic compound, is a naturally occurring highly colored yellow
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …
pigment found in the small intercellular pigment glands in the leaves, stems, roots, and seed …
An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines
ML Leblanc, J Russo, AP Kudelka, JA Smith - Pharmacological research, 2002 - Elsevier
Gossypol, a cottonseed extract, has been shown to have antiproliferative activity in a variety
of cancer cell lines. The objective of this study was to determine the inhibitory effects of …
of cancer cell lines. The objective of this study was to determine the inhibitory effects of …