Revolutionizing drug formulation development: The increasing impact of machine learning
Over the past few years, the adoption of machine learning (ML) techniques has rapidly
expanded across many fields of research including formulation science. At the same time …
expanded across many fields of research including formulation science. At the same time …
Machine learning directed drug formulation development
Abstract Machine learning (ML) has enabled ground-breaking advances in the healthcare
and pharmaceutical sectors, from improvements in cancer diagnosis, to the identification of …
and pharmaceutical sectors, from improvements in cancer diagnosis, to the identification of …
[PDF][PDF] Self-driving laboratories: A paradigm shift in nanomedicine development
Nanomedicines have transformed promising therapeutic agents into clinically approved
medicines with optimal safety and efficacy profiles. This is exemplified by the mRNA …
medicines with optimal safety and efficacy profiles. This is exemplified by the mRNA …
Current status and future perspectives on MRNA drug manufacturing
C Webb, S Ip, NV Bathula, P Popova… - Molecular …, 2022 - ACS Publications
The coronavirus disease of 2019 (COVID-19) pandemic launched an unprecedented global
effort to rapidly develop vaccines to stem the spread of the novel severe acute respiratory …
effort to rapidly develop vaccines to stem the spread of the novel severe acute respiratory …
Role of drug delivery technologies in the success of COVID-19 vaccines: a perspective
The triumphant success of mRNA vaccines is a testimony to the important role drug delivery
technologies have played in protecting billions of people against SARS-CoV-2 (or the …
technologies have played in protecting billions of people against SARS-CoV-2 (or the …
AGILE platform: a deep learning-powered approach to accelerate LNP development for mRNA delivery
Ionizable lipid nanoparticles (LNPs) have seen widespread use in mRNA delivery for clinical
applications, notably in SARS-CoV-2 mRNA vaccines. Despite their successful use …
applications, notably in SARS-CoV-2 mRNA vaccines. Despite their successful use …
Mechanistic studies of an automated lipid nanoparticle reveal critical pharmaceutical properties associated with enhanced mRNA functional delivery in vitro and in …
Recently, lipid nanoparticles (LNPs) have attracted attention due to their emergent use for
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …
COVID‐19 mRNA vaccines. The success of LNPs can be attributed to ionizable lipids, which …
Lipid nanoparticle delivery systems to enable mRNA-based therapeutics
SC Semple, R Leone, CJ Barbosa, YK Tam, PJC Lin - Pharmaceutics, 2022 - mdpi.com
The world raced to develop vaccines to protect against the rapid spread of SARS-CoV-2
infection upon the recognition of COVID-19 as a global pandemic. A broad spectrum of …
infection upon the recognition of COVID-19 as a global pandemic. A broad spectrum of …
Non-liver mRNA delivery
D Loughrey, JE Dahlman - Accounts of chemical research, 2021 - ACS Publications
Conspectus mRNA drugs can preempt infectious disease and treat Mendelian disorders,
such as sickle cell anemia, muscular dystrophy, and cystic fibrosis, as well as autoimmunity …
such as sickle cell anemia, muscular dystrophy, and cystic fibrosis, as well as autoimmunity …
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
SJ Shepherd, X Han, AJ Mukalel… - Proceedings of the …, 2023 - National Acad Sciences
Lipid nanoparticles (LNPs) are a potent delivery technology that have made it possible for
the recent clinical breakthroughs in mRNA therapeutics and vaccines. A key challenge to the …
the recent clinical breakthroughs in mRNA therapeutics and vaccines. A key challenge to the …