Heterochromatin plays a central role in the process of immune evasion, pathogenesis, and
transmission of the malaria parasite Plasmodium falciparum during blood stage infection …

Epigenetic processes are the main conductors of phenotypic variation in eukaryotes. The
malaria parasite Plasmodium falciparum employs antigenic variation of the major surface …

Clonally variant expression of surface antigens allows the malaria parasite Plasmodium
falciparum to evade immune recognition during blood stage infection and secure malaria …

Background Plasmodium falciparum, the causative agent of the most severe form of malaria,
undergoes antigenic variation through successive presentation of a family of antigens on the …

Heterochromatin-dependent gene silencing is central to the adaptation and survival of
Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during …

The most polymorphic gene family in P. falciparum is the∼ 60 var genes distributed across
parasite chromosomes, both in the subtelomeres and in internal regions. They encode …

Heterochromatin-associated gene silencing controls multiple physiological processes in
malaria parasites, however, little is known concerning the regulatory network and cis-acting …

Parasite proteins called PfEMP1 that are inserted on the surface of infected erythrocytes,
play a key role in the severe pathology associated with infection by the Plasmodium …

The heterochromatic environment and physical clustering of chromosome ends at the
nuclear periphery provide a functional and structural framework for antigenic variation and …

Histones, by packaging and organizing the DNA into chromatin, serve as essential building
blocks for eukaryotic life. The basic structure of the chromatin is established by four …