Effective metabolism is highly dependent on a narrow therapeutic range of oxygen.
Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene …

Molecular oxygen (O2) sustains intracellular bioenergetics and is consumed by numerous
biochemical reactions, making it essential for most species on Earth. Accordingly, decreased …

Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove
harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution …

Two antithetic terms, hypoxia and hyperoxia, ie, insufficient and excess oxygen availability
with respect to needs, are thought to trigger opposite responses in cells and tissues. This …

Significance: Oxygen is indispensable for aerobic life, but its utilization exposes cells and
tissues to oxidative stress; thus, tight regulation of cellular, tissue, and systemic oxygen …

Hypoxia, a low O2 tension, is a fundamental feature that occurs in physiological events as
well as pathophysiological conditions, especially mentioned for its role in the mechanism of …

Oxygen is a key molecule for cell metabolism. Eukaryotic cells sense the reduction in
oxygen availability (hypoxia) and trigger a series of cellular and systemic responses to adapt …

The term “normobaric oxygen paradox”(NOP), describes the response to the return to
normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up …

Oxygen homeostasis reflects the constant body requirement to generate energy. Hypoxia
(0.1–1% O2), physioxia or physoxia (∼ 1–13%), and normoxia (∼ 20%) are terms used to …

Oxygen is an essential element in the survival of complex organisms, however the level of
oxygen, low or high, can be a source of stress depending on the biological context. Low …