To achieve homeostasis, cells evolved dynamic and self-regulating quality control
processes to adapt to new environmental conditions and to prevent prolonged damage. We …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

Proteolysis in eukaryotic cells is mainly mediated by the ubiquitin (Ub)-proteasome system
(UPS) and the autophagylysosome system (hereafter autophagy). The UPS is a selective …

Autophagy and the ubiquitin–proteasome system are the two major quality control pathways
responsible for cellular homeostasis. As such, they provide protection against age …

Cells maintain a healthy proteome through continuous evaluation of the quality of each of
their proteins. Quality control requires the coordinated action of chaperones and proteolytic …

Selective degradation of proteins requires a fine-tuned coordination of the two major
proteolytic pathways, the ubiquitin-proteasome system (UPS) and autophagy. Substrate …

In response to environmental stimuli, cells make a series of adaptive changes to combat the
injury, repair the damage, and increase the tolerance to the stress. However, once the …

The living cell is an ever changing, responsive, and adaptive environment where proteins
play key roles in all processes and functions. While the scientific community focused for a …

Two major pathways degrade most cellular proteins in eukaryotic cells: the ubiquitin–
proteasome system (UPS), which usually degrades the majority of proteins, and autophagy …

Far from now are the days when investigators raced to identify the proteolytic system
responsible for the degradation of their favorite protein. Nowadays, it is well accepted that a …