Metagenomic sequencing for infectious disease diagnostics is an important tool that holds
promise for use in the clinical laboratory. Challenges for implementation so far include high …

The gold standard for confirming bacterial infections is culture-positive, which has a long
sample-to-result turnaround time and poor sensitivity for unculturable and fastidious …

Extended turnaround times and large economic costs hinder the usage of currently applied
screening methods for bacterial pathogen identification (ID) and antimicrobial susceptibility …

Recent advances in nanopore sequencing technology have led to a substantial increase in
throughput and sequence quality. Together, these improvements may permit real-time …

Bloodstream infections (BSI) and sepsis are major causes of morbidity and mortality
worldwide. Blood culture-based diagnostics usually requires 1–2 days for identification of …

Since its introduction, nanopore sequencing has enhanced our ability to study complex
microbial samples through the possibility to sequence long reads in real time using …

Metagenomic sequencing with the Oxford Nanopore MinION sequencer offers potential for
point-of-care testing of infectious diseases in clinical settings. To improve cost-effectiveness …

Abstract The MinION sequencer (Oxford Nanopore Technologies) is a paradigm shifting
device allowing rapid, real time long read sequencing of nucleic acids. Yet external …

Fast and accurate identification of microbial pathogens is critical for the proper treatment of
infections. Traditional culture‐based diagnosis in clinics is increasingly supplemented by …

Next-generation whole-genome sequencing is essential for high-resolution surveillance of
bacterial pathogens, for example, during outbreak investigations or for source tracking and …