Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics
P Puchalska, PA Crawford - Cell metabolism, 2017 - cell.com
Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …
Metabolic Messengers: ketone bodies
Prospective molecular targets and therapeutic applications for ketone body metabolism
have increased exponentially in the past decade. Initially considered to be restricted in …
have increased exponentially in the past decade. Initially considered to be restricted in …
Metabolic and signaling roles of ketone bodies in health and disease
P Puchalska, PA Crawford - Annual review of nutrition, 2021 - annualreviews.org
Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …
Modulation of cellular biochemistry, epigenetics and metabolomics by ketone bodies. Implications of the ketogenic diet in the physiology of the organism and …
A Dąbek, M Wojtala, L Pirola, A Balcerczyk - Nutrients, 2020 - mdpi.com
Ketone bodies (KBs), comprising β-hydroxybutyrate, acetoacetate and acetone, are a set of
fuel molecules serving as an alternative energy source to glucose. KBs are mainly produced …
fuel molecules serving as an alternative energy source to glucose. KBs are mainly produced …
[HTML][HTML] Ketone body metabolism and cardiovascular disease
DG Cotter, RC Schugar… - American Journal of …, 2013 - journals.physiology.org
Ketone bodies are metabolized through evolutionarily conserved pathways that support
bioenergetic homeostasis, particularly in brain, heart, and skeletal muscle when …
bioenergetic homeostasis, particularly in brain, heart, and skeletal muscle when …
Molecular mechanisms for ketone body metabolism, signaling functions, and therapeutic potential in cancer
CY Hwang, W Choe, KS Yoon, J Ha, SS Kim, EJ Yeo… - Nutrients, 2022 - mdpi.com
The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …
Ketone bodies: from enemy to friend and guardian angel
H Kolb, K Kempf, M Röhling, M Lenzen-Schulte… - BMC medicine, 2021 - Springer
During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating
insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the …
insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the …
The evolution of ketosis: potential impact on clinical conditions
Ketone bodies are small compounds derived from fatty acids that behave as an alternative
mitochondrial energy source when insulin levels are low, such as during fasting or …
mitochondrial energy source when insulin levels are low, such as during fasting or …
Ketone bodies and cardiovascular disease: an alternate fuel source to the rescue
AS Manolis, TA Manolis, AA Manolis - International Journal of Molecular …, 2023 - mdpi.com
The increased metabolic activity of the heart as a pump involves a high demand of
mitochondrial adenosine triphosphate (ATP) production for its mechanical and electrical …
mitochondrial adenosine triphosphate (ATP) production for its mechanical and electrical …
Multi-dimensional roles of ketone bodies in cancer biology: Opportunities for cancer therapy
S Feng, H Wang, J Liu, AA Jiye, F Zhou… - Pharmacological …, 2019 - Elsevier
Ketone bodies are traditionally viewed as metabolic substrates in carbohydrate restriction
and are applied in the treatment of epilepsy and other neurodegenerative diseases …
and are applied in the treatment of epilepsy and other neurodegenerative diseases …
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