Ketone body metabolism is a central node in physiological homeostasis. In this review, we
discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and …

Prospective molecular targets and therapeutic applications for ketone body metabolism
have increased exponentially in the past decade. Initially considered to be restricted in …

Ketone bodies play significant roles in organismal energy homeostasis, serving as oxidative
fuels, modulators of redox potential, lipogenic precursors, and signals, primarily during …

Ketone bodies (KBs), comprising β-hydroxybutyrate, acetoacetate and acetone, are a set of
fuel molecules serving as an alternative energy source to glucose. KBs are mainly produced …

Ketone bodies are metabolized through evolutionarily conserved pathways that support
bioenergetic homeostasis, particularly in brain, heart, and skeletal muscle when …

The ketone bodies (KBs) β-hydroxybutyrate and acetoacetate are important alternative
energy sources for glucose during nutrient deprivation. KBs synthesized by hepatic …

During starvation, fasting, or a diet containing little digestible carbohydrates, the circulating
insulin levels are decreased. This promotes lipolysis, and the breakdown of fat becomes the …

The increased metabolic activity of the heart as a pump involves a high demand of
mitochondrial adenosine triphosphate (ATP) production for its mechanical and electrical …

Ketone bodies are traditionally viewed as metabolic substrates in carbohydrate restriction
and are applied in the treatment of epilepsy and other neurodegenerative diseases …

Direct regulation of gene expression may occur in-vivo via through ketone body-mediated
histone modifications during adherence to low-carbohydrate diets, fasting ketosis …