The GABAergic system as a therapeutic target for Alzheimer's disease
B Calvo‐Flores Guzmán, C Vinnakota… - Journal of …, 2018 - Wiley Online Library
Glutamatergic and cholinergic dysfunction are well‐attested features of Alzheimer's disease
(AD), progressing with other pathological indices of the disorder and exacerbating neuronal …
(AD), progressing with other pathological indices of the disorder and exacerbating neuronal …
Towards a better understanding of GABAergic remodeling in Alzheimer's disease
K Govindpani, B Calvo-Flores Guzmán… - International journal of …, 2017 - mdpi.com
γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebrate brain.
In the past, there has been a major research drive focused on the dysfunction of the …
In the past, there has been a major research drive focused on the dysfunction of the …
Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway
A Kwakowsky, BCF Guzmán… - Neural regeneration …, 2018 - journals.lww.com
Conclusions: Our findings demonstrated that the GABAergic system suffers significant
remodeling in the brains of AD patients, yet it is to be determined if this is as a consequence …
remodeling in the brains of AD patients, yet it is to be determined if this is as a consequence …
Treatment options in alzheimer s disease: the GABA story
M Solas, E Puerta, MJ Ramirez - Current pharmaceutical …, 2015 - ingentaconnect.com
Alzheimer's disease (AD) is the most common form of dementia in the elderly. Research
focused on identifying compounds that restore cognition and memory in AD patients is a …
focused on identifying compounds that restore cognition and memory in AD patients is a …
The GABAergic system in Alzheimer's disease: a systematic review with meta-analysis
G Carello-Collar, B Bellaver, PCL Ferreira… - Molecular …, 2023 - nature.com
The γ-aminobutyric acid (GABA) ergic system is the primary inhibitory neurotransmission
system in the mammalian brain. Its dysregulation has been shown in multiple brain …
system in the mammalian brain. Its dysregulation has been shown in multiple brain …
GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by
cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two …
cognitive decline, brain atrophy due to neuronal and synapse loss, and formation of two …
Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease
RA Rissman, WC Mobley - Journal of neurochemistry, 2011 - Wiley Online Library
J. Neurochem.(2011) 117, 623–631. Abstract In addition to progressive dementia,
Alzheimer's disease (AD) is characterized by increased incidence of seizure activity …
Alzheimer's disease (AD) is characterized by increased incidence of seizure activity …
GABAA receptors in aging and Alzheimer's disease
RA Rissman, AL De Blas… - Journal of …, 2007 - Wiley Online Library
In this article we present a comprehensive review of relevant research and reports on the
GABAA receptor in the aged and Alzheimer's disease (AD) brain. In comparison to …
GABAA receptor in the aged and Alzheimer's disease (AD) brain. In comparison to …
Implications of GABAergic neurotransmission in Alzheimer's disease
Y Li, H Sun, Z Chen, H Xu, G Bu… - Frontiers in aging …, 2016 - frontiersin.org
Alzheimer's disease (AD) is characterized pathologically by the deposition of β-amyloid
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …
GABAergic inhibitory interneuron deficits in Alzheimer's disease: implications for treatment
Y Xu, M Zhao, Y Han, H Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …
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