Abstract Although interleukin-15 (IL-15) is a powerful immunomodulatory factor that has
been proposed for cancer immunotherapy, its intratumoral expression may be correlated …

Abstract Intrarenal interleukin-15 (IL-15) plays a major role controlling epithelial survival and
polarization both in physiological and pathologic conditions. Herein, we confirmed that …

Although not structurally related, the pleiotropic cytokines interleukin-7 (IL-7) and interleukin-
15 (IL-15) share a variety of biological functions including stimulation and maintenance of …

The ability of Interleukin-15 (IL-15) to activate many immune antitumor mechanisms renders
the cytokine a good candidate for the therapy of solid tumors, particularly renal cell …

Experiments in IL-15−/− and IL-15Rα−/− mice show that intra-renal IL-15, through IL-15Rα
behaves as an epithelial survival factor. Recent data highlight new functions of IL-15 in renal …

Abstract Intrarenal interleukin-15 (IL-15) participates to renal pathophysiology, but the role of
its different membrane-bound isoforms remains to be elucidated. In this study, we reassess …

Interleukin (IL)-21 is a class I cytokine with sequence homology to the IL-2 cytokine
superfamily. IL-21 signals through a heterodimer of a unique IL-21 receptor and the common …

Interleukin (IL)-2 and IL-15 are two cytokine growth factors that regulate lymphocyte function
and homeostasis. Early clinical interest in the use of IL-2 in the immunotherapy of renal cell …

Abstract Interleukin-13 (IL-13) is a cytokine produced primarily by activated T lymphocytes. It
exerts a variety of effects on different cell types, including monocytes, B lymphocytes, mast …

Abstract Interleukin (IL)-21 is a novel cytokine in clinical development for the treatment of
cancer. In this study, we have compared the efficacy of subcutaneous and intratumoral (IT) …