The arrival of multicellularity in evolution facilitated cell–cell signaling in conjunction with
adhesion. As the ectodomains of cadherins interact with each other directly in trans (as well …

The cadherin/catenin complex organizes to form a structural Velcro that joins the
cytoskeletal networks of adjacent cells. Functional loss of this complex arrests the …

Cadherins and associated catenins provide an important structural interface between
neighboring cells, the actin cytoskeleton, and intracellular signaling pathways in a variety of …

The cadherin gene superfamily of calcium-dependent cell-cell adhesion molecules contains
more than 40 members. We summarize functions attributed to these proteins, especially their …

This review addresses the cellular and molecular mechanisms of cadherin-based tissue
morphogenesis. Tissue physiology is profoundly influenced by the distinctive organizations …

Adhesive interactions between cells are dynamic and regulated during tissue development
and homeostasis. Cadherins are major cell–cell adhesion molecules involved in the …

Cadherins form a family of cell‐cell adhesion proteins that are critical to normal embryonic
development. Expression of the various family members is regulated in a complex pattern …

Tissue morphogenesis during development is dependent on activities of the cadherin family
of cell–cell adhesion proteins that includes classical cadherins, protocadherins, and atypical …

This review addresses our current understanding of the regulatory mechanisms for classical
cadherin expression during development of the vertebrate nervous system. The complexity …

Properly regulated intercellular adhesion is critical for normal development of all metazoan
organisms. Adherens junctions play an especially prominent role in development because …