Alcohol consumption and stress increase brain levels of known innate immune signaling
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …

Molecular and behavioral studies corroborate a pivotal role for the innate immune system in
mediating the acute and chronic effects of alcohol and support a neuroimmune hypothesis of …

Rationale Alcoholism is a primary, chronic relapsing disease of brain reward, motivation,
memory, and related circuitry. It is characterized by an individual's continued drinking …

Immune or brain proinflammatory signaling has been linked to some of the behavioral
effects of alcohol. Immune signaling appears to regulate voluntary ethanol intake in rodent …

Abstract Background Athina Markou and her colleagues discovered persistent changes in
adult behavior following adolescent exposure to ethanol or nicotine consistent with …

Innate immune signaling is an important feature in the pathology of alcohol use disorders.
Alcohol abuse causes persistent innate immune activation in the brain. This is seen in …

Addiction occurs through repeated abuse of drugs that progressively reduce behavioral
control and cognitive flexibility while increasing limbic negative emotion. Recent discoveries …

Induction of neuroimmune genes by binge drinking increases neuronal excitability and
oxidative stress, contributing to the neurobiology of alcohol dependence and causing …

Alcohol use disorder (AUD) is a widespread disease with limited treatment options.
Targeting the neuroimmune system is a new avenue for developing or repurposing effective …

Alcohol abuse changes behavior and can induce major mood disorders such as depression.
Recent evidence in pre-clinical rodent models and humans now supports the conclusion …