miR-155 influences cell-mediated immunity in Balb/c mice treated with aflatoxin M1

K Shirani, B Riahi Zanjani, S Mehri… - Drug and chemical …, 2021 - Taylor & Francis
Abstract Aflatoxin M1 (AFM1) is a 4-hydroxylated metabolite of aflatoxin B1 (AFB1). It
induces various toxicological effects including immunotoxicity. In the present study, we …

In vitro study of AFB1 and AFM1 effects on human lymphoblastoid Jurkat T-cell model

D Luongo, R Russo, A Balestrieri… - Journal of …, 2014 - Taylor & Francis
Abstract Aflatoxin B1 (AFB1) is a mycotoxin produced by Aspergillus spp. that can occur as a
natural contaminant in foods and feeds of vegetable origin. Post-ingestion, AFB1 can be …

Immunotoxicity of aflatoxin M1: as a potent suppressor of innate and acquired immune systems in a subacute study

K Shirani, BR Zanjani, M Mahmoudi… - Journal of the …, 2018 - Wiley Online Library
BACKGROUND Although, to date, there have been several in vitro and in vivo studies of
immunomodulatory effects of aflatoxin M1 (AFB1), little is known about the effect of AFM1 on …

Modulation of macrophage activity by aflatoxins B1 and B2 and their metabolites aflatoxins M1 and M2

G Bianco, R Russo, S Marzocco, S Velotto, G Autore… - Toxicon, 2012 - Elsevier
Aflatoxins are natural contaminants frequently found both in food and feed. Many of them
exert immunomodulatory properties in mammals; therefore, the aim of the current study was …

Aflatoxin B1 modulates the expression of phenotypic markers and cytokines by splenic lymphocytes of male F344 rats

G Qian, L Tang, X Guo, F Wang… - Journal of Applied …, 2014 - Wiley Online Library
ABSTRACT Aflatoxin B1 (AFB1) is immunotoxic to animals and a suspected
immunosuppressant in humans. In this study, we investigated the effects of AFB1 on splenic …

Modulating effect of MgO-SiO2 nanoparticles on immunological and histopathological alterations induced by aflatoxicosis in rats

SS Essa, EM El-Saied, OS El-Tawil, MB Mahmoud… - Toxicon, 2017 - Elsevier
Abstract Introduction AflatoxinB1 (AFB1) is well-known as a feed borne-hepatotoxic and
immunosuppressive mycotoxin. This study was conducted to evaluate the efficacy of …

Upregulation of miR-34a-5p antagonizes AFB1-induced genotoxicity in F344 rat liver

C Liu, H Yu, Y Zhang, D Li, X Xing, L Chen, X Zeng… - Toxicon, 2015 - Elsevier
Abstract Aflatoxin B1 (AFB1) is a well-known human hepatotoxicant and genotoxicant.
Recent studies demonstrated that aberrant miRNA expression patterns were correlated with …

Inhibition of various functions in murine peritoneal macrophages by aflatoxin B1 exposure in vivo

EY Moon, DK Rhee, S Pyo - International journal of immunopharmacology, 1999 - Elsevier
Aflatoxin B1 (AFB1) has been known to impair specific and nonspecific immunity. In the
present study, we tested various functions of murine peritoneal macrophages that were …

[HTML][HTML] Toxicity mechanisms of aflatoxin M1 assisted with molecular docking and the toxicity-limiting role of trans-resveratrol

İ Güç, E Yalçin, K Çavuşoğlu, A Acar - Scientific Reports, 2022 - nature.com
In this study, AFM1 toxicity and the protective role of trans-resveratrol (t-rsv) against this
toxicity were investigated with the help of multiple parameters in albino mice. As a result …

[HTML][HTML] The Expression of MMP1 and MMP7 in Mice Liver after Exposure to Aflatoxin B1 Using Immunohistochemistry Technique

NHA Al-Mudallal - Archives of Razi Institute, 2023 - ncbi.nlm.nih.gov
Mycotoxin is a class of poisonous secondary metabolites generated by filamentous fungi
and found in agricultural commodities worldwide. Therefore, the current study aimed to …