The role of classical and non-classical estrogen receptors (ERs) in mediating the
neuroprotective effects of this hormone on brain edema and long-term behavioral disorders …

Object Although there is evidence that estradiol has neuroprotective effects after traumatic
brain injury (TBI) in female rats, it is unclear which estrogen receptor (ER) subtype, ERα or …

It has been demonstrated that estradiol has neuroprotective effects after traumatic brain
injury (TBI) in female rats. Since estrogen receptors have an important role in estradiol …

Background 17β-estradiol (E2) has been implicated to exert neuroprotective effects in the
brain following cerebral ischemia. Classically, E2 is thought to exert its effects via genomic …

Background: In previous studies, the neuroprotective effect of 17β-estradiol in diffuse
traumatic brain injury has been shown. This study used ICI 182,780, a non-selective …

The G protein-coupled estrogen receptor (GPER) plays a role in estrogen-mediated
neuroprotection and has been considered a potential therapeutic target for treating various …

Traumatic brain injury (TBI) is a significant public health problem in the United States.
Despite preclinical success of various drugs, to date all clinical trials investigating potential …

Stroke is a leading cause of permanent disability and death. It is well accepted that the
principal mammalian estrogen (E2), 17-β estradiol, provides robust neuroprotection in a …

Estrogen receptor (ER) mediated neuroprotection has been demonstrated in both in vitro
and in vivo model systems. However, the relative contribution by either ER subtype, ERα or …

Estrogen receptor (ER) activation by 17-ß estradiol (E2) can attenuate neuronal injury and
behavioral impairments following global cerebral ischemia (GCI) in rodents. This study …