Purpose Despite the numerous studies on the factors involved in the genesis and growth of
uterine leiomyomas, the pathogenesis of these tumors remains unknown. Intrinsic …

BACKGROUND Uterine leiomyomas (fibroids) are highly prevalent benign smooth muscle
tumors of the uterus. In the USA, the lifetime risk for women developing uterine leiomyomas …

Highlights•Race/ethnicity is the most consistent factor associated with fibroid
development.•Direct cause of genetics and the genesis of fibroids remain uncertain.•Models …

Uterine leiomyomas are benign smooth-muscle tumors of extremely low malignant potential.
Early work utilizing classical cytogenetics revealed that a subset of uterine leiomyomas …

Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

OBJECTIVE: To summarize the information regarding pathogenetic factors of leiomyoma
formation and growth, and to make a simple integrated pathogenetic view of this tumor for …

Uterine leiomyomas are monoclonal tumors. However, the factors involved in their initiation
and growth remain poorly understood. The neoplastic transformation of myometrium to …

BACKGROUND: Uterine leiomyomas are extremely common and a major cause of pelvic
pain, bleeding, infertility, and the leading indication for hysterectomy. Familial and …

Background Uterine leiomyomas are benign but affect the health of millions of women. A
better understanding of the molecular mechanisms involved may provide clues to the …

Purpose Uterine leiomyomas are common, benign, reproductive tract tumors affecting a
majority of reproductive aged women. They are associated with gynecologic morbidity and …