Hepatic cholesterol overload promotes steatohepatitis. Insufficient understanding of liver
stress defense impedes therapy development. Here, we elucidate the role of stress defense …

High density lipoproteins (HDL) promote homeostasis and counteract stressful tissue
damage that underlie cardiovascular and other diseases by mediating reverse cholesterol …

Background The transcription factor nuclear factor-E2-related factor-2 (Nrf2) inhibits lipid
accumulation and oxidative stress in the liver by interfering with lipogenic pathways and …

Oxidative stress is a key driver in the development and progression of several diseases,
including metabolic associated fatty liver disease (MAFLD). This condition includes a wide …

Nuclear factor erythroid-2 related factor 2 (Nrf2) plays a pivotal role in cytoprotection against
both endogenous and exogenous stresses. Here, we establish a novel molecular link …

Cholesterol is a critical nutrient requiring tight constraint in the endoplasmic reticulum (ER)
due to its uniquely challenging biophysical properties. While the mechanisms by which the …

Oxidative stress is a critical mediator in liver injury of steatohepatitis. The transcription factor
Nrf2 serves as a cellular stress sensor and is a key regulator for induction of hepatic …

Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease with ever‐growing
incidence in the industrialized world. It starts with the simple accumulation of lipids in the …

Hepatic lipid metabolism is under elaborate regulation, and perturbations in this regulatory
process at the transcriptional level lead to pathological conditions. NF-E2-related factor 1 …

Background The transcription factor nuclear factor-E2-related factor-2 (Nrf2) is a key
regulator for induction of hepatic antioxidative stress systems. We aimed to investigate …