Infections caused by multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-
negative bacteria (GNB), including carbapenem-resistant (CR) Enterobacterales (CRE; …

The prevalence of carbapenem-resistant gram-negative bacterial pathogens (CRGNs) has
increased dramatically during the last 10 years, but the optimal treatment for CRGN …

Background Carbapenem-resistant gram-negative bacteria (CRGNB) continue to present a
global healthcare crisis. We aimed to identify emerging trends of CRGNB over nearly 2 …

High-resistance rates in carbapenem-resistant GNB in many countries will inevitably
complicate treatment of serious infections in vulnerable patient groups and should …

Highlights•Carbapenem-resistant Gram-negative pathogens are a priority for R&D,
according to WHO.•Increasing need for new therapies against Klebsiella, Pseudomonas and …

Infections due to multidrug-resistant Enterobacteriaceae have become major international
public health problem due to the inadequate treatment options and the historically lagged …

Infectious disease outbreaks have caused thousands of deaths and hospitalizations, along
with severe negative global economic impacts. Among these, infections caused by …

Carbapenem-resistant Enterobacteriaceae (CRE), a major resistance concern emerging
during the last decade because of significantly compromising the efficacy of carbapenem …

The recent expansion of multidrug resistant and pan-drug-resistant pathogens poses
significant challenges in the treatment of healthcare associated infections. An important …

The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global
public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug …