Accumulating evidence supports the association of somatic mutations with tumor occurrence
and development. We aimed to identify somatic mutations with important implications in …

Background: Hepatocellular carcinoma (HCC) is one of the most leading causes of cancer-
related mortality worldwide. Immune checkpoint inhibitors (ICIs) have been proved to be …

Hepatocellular carcinoma (HCC) is one of the most common malignancies globally and the
second leading cause of cancer-related death. Low-density lipoprotein (LDL) receptor …

Background New predictors of the efficacy of hepatocellular carcinoma (HCC)
immunotherapy are needed. The ability of a single gene mutation to predict the therapeutic …

Low-density lipoprotein receptor-related protein 1B (LRP1B) is a giant member of the LDLR
protein family, which includes several structurally homologous cell surface receptors with a …

High-grade serous cancer (HGSC), the most common subtype of ovarian cancer, often
becomes resistant to chemotherapy, leading to poor patient outcomes. Intratumoral …

Loss of apico-basal polarity often results in a malignant phenotype in epithelial tissues.
Aberrant expression of polarity mediator proteins is closely associated with this process …

Background The low-density lipoprotein receptor-related protein-1 (LRP-1) is an endocytic
receptor mediating the clearance of various extracellular molecules involved in the …

Background: Long noncoding RNA (lncRNA)-PRLB (progression-associated lncRNA in
breast cancer) has been identified to enhance the drug resistance of breast cancer cells. In …

Hepatocellular carcinoma (HCC) has a high recurrence rate and mortality rate even after
surgery. Low-density lipoprotein receptor-related protein 1B (LRP1B) has proven to be …