Alzheimer disease (AD) is a medically and financially overwhelming condition, and
incidence rates are expected to triple by 2050. Despite decades of research in animal …

A major impediment to the development of safe and effective therapeutics in Alzheimer's
disease (AD) lies in difficulties in translating research findings across species: therapies that …

Animal models have contributed significantly to our understanding of the underlying
biological mechanisms of Alzheimer's disease (AD). As a result, over 300 interventions have …

Alzheimer's disease (AD), an irreversible neurodegenerative disease that progressively
impairs memory and cognitive judgment, severely affects the quality of life and imposes a …

Substantial resources and effort have been invested into the development of therapeutic
agents for Alzheimer's disease (AD) with mixed and limited success. Research into the …

Over 5 million Americans and 50 million individuals worldwide are living with Alzheimer's
disease (AD). The progressive dementia associated with AD currently has no cure. Although …

Animal models are indispensable tools for Alzheimer disease (AD) research. Over the
course of more than two decades, an increasing number of complementary rodent models …

The increasing prevalence of Alzheimer's disease (AD) poses a considerable socio‐
economic challenge. Decades of experimental research have not led to the development of …

A large number of mouse models have been engineered, characterized and used to
advance biomedical research in Alzheimer disease (AD). Early models simply damaged the …

Significant insights into the function of genes associated with Alzheimer disease and related
dementias have occurred through studying genetically modified animals. Although none of …