Microfluidic platforms for mechanobiology

WJ Polacheck, R Li, SGM Uzel, RD Kamm - Lab on a Chip, 2013 - pubs.rsc.org
Mechanotransduction has been a topic of considerable interest since early studies
demonstrated a link between mechanical force and biological response. Until recently …

A new mechanobiological era: microfluidic pathways to apply and sense forces at the cellular level

F Kurth, K Eyer, A Franco-Obregón… - Current opinion in chemical …, 2012 - Elsevier
Fueled by technological advances in micromanipulation methodologies, the field of
mechanobiology has boomed in the last decade. Increasing needs for clinical solutions to …

Microfluidics as a functional tool for cell mechanics

SA Vanapalli, MHG Duits, F Mugele - Biomicrofluidics, 2009 - pubs.aip.org
Living cells are a fascinating demonstration of nature's most intricate and well-coordinated
micromechanical objects. They crawl, spread, contract, and relax—thus performing a …

(Micro) managing the mechanical microenvironment

C Moraes, Y Sun, CA Simmons - Integrative Biology, 2011 - academic.oup.com
Mechanical forces are critical components of the cellular microenvironment and play a
pivotal role in driving cellular processes in vivo. Dissecting cellular responses to mechanical …

Micropillar substrates: a tool for studying cell mechanobiology

M Gupta, L Kocgozlu, BR Sarangi, F Margadant… - Methods in cell …, 2015 - Elsevier
Increasing evidence has shown that mechanical cues from the environment play an
important role in cell biology. Mechanotransduction or the study of how cells can sense …

Mechanotransduction: use the force (s)

EK Paluch, CM Nelson, N Biais, B Fabry, J Moeller… - BMC biology, 2015 - Springer
Mechanotransduction-how cells sense physical forces and translate them into biochemical
and biological responses-is a vibrant and rapidly-progressing field, and is important for a …

Microengineered platforms for cell mechanobiology

DH Kim, PK Wong, J Park… - Annual review of …, 2009 - annualreviews.org
Mechanical forces play important roles in the regulation of various biological processes at
the molecular and cellular level, such as gene expression, adhesion, migration, and cell …

[HTML][HTML] Decoding mechanical cues by molecular mechanotransduction

V Swaminathan, M Gloerich - Current opinion in cell biology, 2021 - Elsevier
Cells are exposed to a variety of mechanical cues, including forces from their local
environment and physical properties of the tissue. These mechanical cues regulate a vast …

Small force, big impact: Next generation organ-on-a-chip systems incorporating biomechanical cues

E Ergir, B Bachmann, H Redl, G Forte, P Ertl - Frontiers in physiology, 2018 - frontiersin.org
Mechanobiology-on-a-chip is a growing field focusing on how mechanical inputs modulate
physico-chemical output in microphysiological systems. It is well known that biomechanical …

Micropipette-based biomechanical nanotools on living cells

H Wang, F Zhou, Y Guo, LA Ju - European Biophysics Journal, 2022 - Springer
Mechanobiology is an emerging field at the interface of biology and mechanics,
investigating the roles of mechanical forces within biomolecules, organelles, cells, and …