Parkinson's disease: a short story of 200 years

L Cuenca, AL Gil Martinez, L Cano Fernandez… - 2019 - digitum.um.es
After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and
incidental neurodegenerative disorder, affecting more than 2% of the population older than …

[HTML][HTML] Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches

Y Huang, J Wei, A Cooper, MJ Morris - Genes & diseases, 2023 - Elsevier
Parkinson's disease (PD) is the most common neurodegenerative movement disorder in the
elderly. As the pathogenesis of PD is still not fully understood, medications with the capacity …

The two-century journey of Parkinson disease research

S Przedborski - Nature Reviews Neuroscience, 2017 - nature.com
Since the first formal description of Parkinson disease (PD) two centuries ago, our
understanding of this common neurodegenerative disorder has expanded at all levels of …

[HTML][HTML] Advances in the mechanisms of Parkinson's disease

CM Tolleson, JY Fang - Discovery medicine, 2013 - discoverymedicine.com
Parkinson's disease is the second most common neurodegenerative disorder. Despite fairly
typical clinical and pathologic features, the etiology remains unknown. Many cellular …

Parkinson's disease

GJA Macphee, DA Stewart - Reviews in Clinical Gerontology, 2006 - cambridge.org
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized
typically by motor features of tremor, rigidity and bradykinesia due to depletion of …

Recent advances in our understanding of Parkinson's disease

SW Kim, HS Ko, VL Dawson, TM Dawson - Drug Discovery Today: Disease …, 2005 - Elsevier
Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease with
complex causes. Through scientific investigation of the gene products identified to be linked …

Biomarkers of Parkinson's disease: present and future

DB Miller, JP O'Callaghan - Metabolism, 2015 - Elsevier
Sporadic or idiopathic Parkinson's disease (PD) is an age-related neurodegenerative
disorder of unknown origin that ranks only second behind Alzheimer's disease (AD) in …

[HTML][HTML] Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments

P Maiti, J Manna, GL Dunbar - Translational neurodegeneration, 2017 - Springer
Gradual degeneration and loss of dopaminergic neurons in the substantia nigra, pars
compacta and subsequent reduction of dopamine levels in striatum are associated with …

Parkinson's disease: from molecular pathways in disease to therapeutic approaches

B Thomas - Antioxidants & redox signaling, 2009 - liebertpub.com
Parkinson's disease (PD) is a complex multifactor disease marked by extensive
neuropathology in the brain with selective yet prominent and progressive loss of midbrain …

Parkinson's disease: an update on pathogenesis and treatment

T Foltynie, J Kahan - Journal of neurology, 2013 - Springer
The Parkinson's disease research field is a rapidly moving one, as many of the relevant
processes underlying PD neurodegeneration are being deciphered, enabling novel …