This year marks the 20th anniversary of the discovery of leptin, which has tremendously
stimulated translational obesity research. The discovery of leptin has led to realizations that …

Adipose tissue is no longer regarded as a non-secretory, inert, depot storage tissue, that
only serves the purposes of insulating the body from cold and/or merely storing energy that …

Historically, adipose tissue was considered to be a passive storage vessel discharging
nutrients in times of famine and accumulating fat in times of surfeit. This view changed with …

Leptin has central importance in the global obesity and cardiovascular disease problem.
Leptin is principally secreted by adipocytes and acts in the hypothalamus to suppress …

Leptin is an adipocyte-derived hormone that primarily acts in the hypothalamus and plays a
key role in the regulation of food intake, body weight, energy expenditure and …

THE DISCOVERY of leptin in 1994 has provided a major new piece in the puzzle of obesity.
Leptin is a 167-amino acid peptide made exclusively in adipose tissue. Its absence …

The molecular mechanisms of body weight and body composition regulation have long
been a research focus in the hopes of identifying tractable pathways for therapeutic …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

Leptin has key roles in the regulation of energy balance, body weight, metabolism, and
endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy …