Highlights•Transcription factors are generally dysregulated in tumors.•Most oncogenic
transcription factors are considered as “undruggable” targets.•Post-translational …

Transcription factors (TFs) are commonly deregulated in the pathogenesis of human cancer
and are a major class of cancer cell dependencies. Consequently, targeting of TFs can be …

Dysregulation or mutation of DNA binding proteins such as transcription factors (TFs) is
associated with the onset and progression of various types of disease, including cancer …

Transcription factors (TFs) specifically bind to DNA, recruit cofactor proteins and modulate
target gene expression, rendering them essential roles in the regulation of numerous …

Mutated or dysregulated transcription factors represent a unique class of drug targets that
mediate aberrant gene expression, including blockade of differentiation and cell death gene …

Cancer is defined by the presence of uncontrollable cell growth, whereby improper
proliferative signaling has overcome regulation by cellular mechanisms. Transcription …

As investigators uncover the molecular pathways leading to cancer, an abundance of
potential molecular targets is accumulating. Among these targets, transcription factors are …

More and more in-depth studies have revealed that the occurrence and development of
tumors depend on gene mutation and tumor heterogeneity. The most important …

The key proteins involved in transcriptional regulation play convergent roles in cellular
homeostasis, and their dysfunction mediates aberrant gene expressions that underline the …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …