Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans
This article describes the fabrication of a microfluidic device for the liquid culture of many
individual nematode worms (Caenorhabditis elegans) in separate chambers. Each chamber …
individual nematode worms (Caenorhabditis elegans) in separate chambers. Each chamber …
A microfabricated array of clamps for immobilizing and imaging C. elegans
This paper describes the fabrication of a microfluidic device for rapid immobilization of large
numbers of live C. elegans for performing morphological analysis, microsurgery, and …
numbers of live C. elegans for performing morphological analysis, microsurgery, and …
Microfluidic chamber arrays for whole-organism behavior-based chemical screening
The nematode Caenorhabditis elegans is an important model organism in genetic research
and drug screening because of its relative simplicity, ease of maintenance, amenability to …
and drug screening because of its relative simplicity, ease of maintenance, amenability to …
Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans
The nematode C. elegans (worm) is a small invertebrate animal widely used in studies
related to fundamental biological processes, disease modelling, and drug discovery. Due to …
related to fundamental biological processes, disease modelling, and drug discovery. Due to …
A microfluidic platform for high-sensitivity, real-time drug screening on C. elegans and parasitic nematodes
JA Carr, A Parashar, R Gibson, AP Robertson… - Lab on a Chip, 2011 - pubs.rsc.org
This paper describes a new microfluidic platform for screening drugs and their dose
response on the locomotion behavior of free living nematodes and parasitic nematodes. The …
response on the locomotion behavior of free living nematodes and parasitic nematodes. The …
NemaLife chip: a micropillar-based microfluidic culture device optimized for aging studies in crawling C. elegans
M Rahman, H Edwards, N Birze, R Gabrilska… - Scientific reports, 2020 - nature.com
In this study, we report a microfluidic device for the whole-life culture of the nematode
Caenorhabditis elegans that allows the scoring of animal survival and health measures. This …
Caenorhabditis elegans that allows the scoring of animal survival and health measures. This …
Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans
M Cornaglia, T Lehnert, MAM Gijs - Lab on a Chip, 2017 - pubs.rsc.org
In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …
CO 2 and compressive immobilization of C. elegans on-chip
We present two microfluidic approaches for immobilizing the roundworm C. elegans on-chip.
The first approach creates a CO2 micro-environment while the second one utilizes a …
The first approach creates a CO2 micro-environment while the second one utilizes a …
Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging
The roundworm C. elegans is a mainstay of aging research due to its short lifespan and
easily manipulable genetics. Current, widely used methods for long-term measurement of C …
easily manipulable genetics. Current, widely used methods for long-term measurement of C …
[HTML][HTML] Microfluidics as a tool for C. elegans research
A San-Miguel, H Lu - WormBook: The Online Review of C. elegans …, 2018 - ncbi.nlm.nih.gov
Microfluidics has emerged as a set of powerful tools that have greatly advanced some areas
of biological research, including research using C. elegans. The use of microfluidics has …
of biological research, including research using C. elegans. The use of microfluidics has …