The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms
Background Previous studies show that antibiotic-mediated (abx) alteration of the gut
microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory …
microbiome (GMB) results in a reduction of amyloid beta (Aβ) plaques and proinflammatory …
Gut microbiota–driven brain Aβ amyloidosis in mice requires microglia
We previously demonstrated that lifelong antibiotic (ABX) perturbations of the gut
microbiome in male APPPS1-21 mice lead to reductions in amyloid β (Aβ) plaque pathology …
microbiome in male APPPS1-21 mice lead to reductions in amyloid β (Aβ) plaque pathology …
Sex-specific effects of microbiome perturbations on cerebral Aβ amyloidosis and microglia phenotypes
We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated
with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid …
with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid …
Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease
Severe amyloidosis and plaque-localized neuro-inflammation are key pathological features
of Alzheimer's disease (AD). In addition to astrocyte and microglial reactivity, emerging …
of Alzheimer's disease (AD). In addition to astrocyte and microglial reactivity, emerging …
Different effects of constitutive and induced microbiota modulation on microglia in a mouse model of Alzheimer's disease
C Mezö, N Dokalis, O Mossad, O Staszewski… - Acta neuropathologica …, 2020 - Springer
It was recently revealed that gut microbiota promote amyloid-beta (Aβ) burden in mouse
models of Alzheimer's disease (AD). However, the underlying mechanisms when using …
models of Alzheimer's disease (AD). However, the underlying mechanisms when using …
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
A Cattaneo, N Cattane, S Galluzzi, S Provasi… - Neurobiology of …, 2017 - Elsevier
The pathway leading from amyloid-β deposition to cognitive impairment is believed to be a
cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid …
cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid …
Exploring the microbiota-Alzheimer's disease linkage using short-term antibiotic treatment followed by fecal microbiota transplantation
Gut microbiota is proven to be involved in the development of beta amyloid (Aβ) pathology in
Alzheimer's disease (AD). Since there are difficulties in translating microbiota findings based …
Alzheimer's disease (AD). Since there are difficulties in translating microbiota findings based …
Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice
HB Dodiya, M Frith, A Sidebottom, Y Cao, J Koval… - Scientific reports, 2020 - nature.com
In preceding efforts, we demonstrated that antibiotic (ABX) cocktail-mediated perturbations
of the gut microbiome in two independent transgenic lines, termed APP SWE/PS1 ΔE9 and …
of the gut microbiome in two independent transgenic lines, termed APP SWE/PS1 ΔE9 and …
Chronic-antibiotics induced gut microbiota dysbiosis rescues memory impairment and reduces β-amyloid aggregation in a preclinical Alzheimer's disease model
PC Bello-Medina, K Corona-Cervantes… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a multifactorial pathology characterized by β-amyloid (Aβ)
deposits, Tau hyperphosphorylation, neuroinflammatory response, and cognitive deficit …
deposits, Tau hyperphosphorylation, neuroinflammatory response, and cognitive deficit …
Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota
T Harach, N Marungruang, N Duthilleul, V Cheatham… - Scientific reports, 2017 - nature.com
Alzheimer's disease is the most common form of dementia in the western world, however
there is no cure available for this devastating neurodegenerative disorder. Despite clinical …
there is no cure available for this devastating neurodegenerative disorder. Despite clinical …