[HTML][HTML] Integrative neuroinformatics for precision prognostication and personalized therapeutics in moderate and severe traumatic brain injury
Despite changes in guideline-based management of moderate/severe traumatic brain injury
(TBI) over the preceding decades, little impact on mortality and morbidity have been seen …
(TBI) over the preceding decades, little impact on mortality and morbidity have been seen …
[HTML][HTML] A precision medicine agenda in traumatic brain injury
J Cruz Navarro, LL Ponce Mejia… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury remains a leading cause of death and disability across the globe.
Substantial uncertainty in outcome prediction continues to be the rule notwithstanding the …
Substantial uncertainty in outcome prediction continues to be the rule notwithstanding the …
A framework to advance biomarker development in the diagnosis, outcome prediction, and treatment of traumatic brain injury
EA Wilde, IB Wanner, K Kenney, J Gill… - Journal of …, 2022 - liebertpub.com
Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …
injury (TBI) endophenotypes are necessary to guide the development of personalized and …
An update on traumatic brain injuries.
SD Timmons - Journal of neurosurgical sciences, 2012 - europepmc.org
Severe traumatic brain injury (TBI) represents a major cause of neurological mortality and
morbidity throughout the world. Several challenges have been faced in the conduct of …
morbidity throughout the world. Several challenges have been faced in the conduct of …
Critical care management of traumatic brain injury
Traumatic brain injury (TBI) is a growing global problem, which is responsible for a
substantial burden of disability and death, and which generates substantial healthcare costs …
substantial burden of disability and death, and which generates substantial healthcare costs …
[HTML][HTML] Neuroinformatics challenges to the structural, connectomic, functional and electrophysiological multimodal imaging of human traumatic brain injury
Throughout the past few decades, the ability to treat and rehabilitate traumatic brain injury
(TBI) patients has become critically reliant upon the use of neuroimaging to acquire …
(TBI) patients has become critically reliant upon the use of neuroimaging to acquire …
[HTML][HTML] Advances in neuroproteomics for neurotrauma: unraveling insights for personalized medicine and future prospects
Neuroproteomics, an emerging field at the intersection of neuroscience and proteomics, has
garnered significant attention in the context of neurotrauma research. Neuroproteomics …
garnered significant attention in the context of neurotrauma research. Neuroproteomics …
Biomarkers for traumatic brain injury: data standards and statistical considerations
Recent biomarker innovations hold potential for transforming diagnosis, prognostic
modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many …
modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many …
Unsupervised machine learning reveals novel traumatic brain injury patient phenotypes with distinct acute injury profiles and long-term outcomes
The heterogeneity of traumatic brain injury (TBI) remains a core challenge for the success of
interventional clinical trials. Data-driven approaches for patient stratification may help to …
interventional clinical trials. Data-driven approaches for patient stratification may help to …
Phenotyping the spectrum of traumatic brain injury: a review and pathway to standardization
It is widely appreciated that the spectrum of traumatic brain injury (TBI), mild through severe,
contains distinct clinical presentations, variably referred to as subtypes, phenotypes, and/or …
contains distinct clinical presentations, variably referred to as subtypes, phenotypes, and/or …