[HTML][HTML] Integrative neuroinformatics for precision prognostication and personalized therapeutics in moderate and severe traumatic brain injury

FA Zeiler, Y Iturria-Medina, EP Thelin, A Gomez… - Frontiers in …, 2021 - frontiersin.org
Despite changes in guideline-based management of moderate/severe traumatic brain injury
(TBI) over the preceding decades, little impact on mortality and morbidity have been seen …

[HTML][HTML] A precision medicine agenda in traumatic brain injury

J Cruz Navarro, LL Ponce Mejia… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury remains a leading cause of death and disability across the globe.
Substantial uncertainty in outcome prediction continues to be the rule notwithstanding the …

A framework to advance biomarker development in the diagnosis, outcome prediction, and treatment of traumatic brain injury

EA Wilde, IB Wanner, K Kenney, J Gill… - Journal of …, 2022 - liebertpub.com
Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …

An update on traumatic brain injuries.

SD Timmons - Journal of neurosurgical sciences, 2012 - europepmc.org
Severe traumatic brain injury (TBI) represents a major cause of neurological mortality and
morbidity throughout the world. Several challenges have been faced in the conduct of …

Critical care management of traumatic brain injury

DK Menon, A Ercole - Handbook of clinical neurology, 2017 - Elsevier
Traumatic brain injury (TBI) is a growing global problem, which is responsible for a
substantial burden of disability and death, and which generates substantial healthcare costs …

[HTML][HTML] Neuroinformatics challenges to the structural, connectomic, functional and electrophysiological multimodal imaging of human traumatic brain injury

SYM Goh, A Irimia, CM Torgerson… - Frontiers in …, 2014 - frontiersin.org
Throughout the past few decades, the ability to treat and rehabilitate traumatic brain injury
(TBI) patients has become critically reliant upon the use of neuroimaging to acquire …

[HTML][HTML] Advances in neuroproteomics for neurotrauma: unraveling insights for personalized medicine and future prospects

F Kobeissy, M Goli, H Yadikar, Z Shakkour… - Frontiers in …, 2023 - frontiersin.org
Neuroproteomics, an emerging field at the intersection of neuroscience and proteomics, has
garnered significant attention in the context of neurotrauma research. Neuroproteomics …

Biomarkers for traumatic brain injury: data standards and statistical considerations

JR Huie, S Mondello, CJ Lindsell, L Antiga… - Journal of …, 2021 - liebertpub.com
Recent biomarker innovations hold potential for transforming diagnosis, prognostic
modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many …

Unsupervised machine learning reveals novel traumatic brain injury patient phenotypes with distinct acute injury profiles and long-term outcomes

KA Folweiler, DK Sandsmark, R Diaz-Arrastia… - Journal of …, 2020 - liebertpub.com
The heterogeneity of traumatic brain injury (TBI) remains a core challenge for the success of
interventional clinical trials. Data-driven approaches for patient stratification may help to …

Phenotyping the spectrum of traumatic brain injury: a review and pathway to standardization

MJ Pugh, E Kennedy, EM Prager… - Journal of …, 2021 - liebertpub.com
It is widely appreciated that the spectrum of traumatic brain injury (TBI), mild through severe,
contains distinct clinical presentations, variably referred to as subtypes, phenotypes, and/or …