Well-known risk factors for atherosclerosis include hypercholesterolaemia, hypertension,
diabetes, and smoking. These conditions are associated with endothelial dysfunction, which …

Endothelial dysfunction defined as the impaired ability of vascular endothelium to stimulate
vasodilation plays a key role in the development of atherosclerosis and in various …

Nitric oxide (NO) produced by endothelial NO synthase (eNOS) represents an anti-
atherosclerotic principle. NO bioavailability is decreased in atherosclerosis due to increased …

Nitric oxide is a soluble gas continuously synthesized by the endothelium. This substance
has a wide range of biological properties that maintain vascular homeostasis, including …

Nitric oxide (NO) is a relative newcomer to pharmacology, as the paper which initiated the
field was published only 25 years ago. Nevertheless its impact is such that to date more than …

Amyl nitrite was introduced in 1867 as the first molecule of a new class of agents for the
treatment of angina pectoris. In the following 150 years, the nitric oxide pathway has been …

Endothelial dysfunction has been shown in a wide range of vascular desorders including
atherosclerosis and related diseases. Here, we examine and address the complex …

The endothelium is a single cell layer that lines all blood vessels. This tissue produces an
impressive array of paracrine factors that maintain vascular homeostasis. One of these …

This review describes the ability of certain diseases, such as essential hypertension,
atherosclerosis, angina, and vasospasm, to reduce vascular nitric oxide (NO) formation or to …

Nitric oxide (NO) has important roles in physiological vasodilatation, cytotoxicity and
vascular disease. Nitric oxide and prostacyclin (PGI2), both released from the endothelium …