The nervous system requires metabolites and oxygen supplied by the neurovascular
network, but this necessitates close apposition of neurons and endothelial cells. We find …

How the vascular and neural compartment cooperate to achieve such a complex and highly
specialized structure as the central nervous system is still unclear. Here, we reveal a …

Formation of a precise vascular network within the central nervous system is of critical
importance to assure delivery of oxygen and nutrients and for accurate functionality of …

Common factors are thought to control vascular and neuronal patterning. Here we report an
in vivo requirement for the vascular endothelial growth factor receptor type 2 (VEGFR2) in …

Blood vessels and nerve fibres course throughout the body in an orderly pattern, often
alongside one another. Although superficially distinct, the mechanisms involved in wiring …

Major vessels of the vertebrate circulatory system display evolutionarily conserved and
reproducible anatomy, but the cues guiding this stereotypic patterning remain obscure. In …

Brain perfusion is tightly coupled to neuronal activity, is commonly used to monitor normal or
pathological brain function, and is a direct reflection of the interactions that occur between …

Blood vessels and nerves are structured in architecturally similar organ systems and show
functional relationships. Indeed, vascular and neuronal cells are guided in their journey …

Class 3 secreted semaphorins (Sema3A–3G) participate in many aspects of axon guidance
through holoreceptor complexes that include Neuropilin-1 (Npn-1) or Neuropilin-2 and one …

Endothelial cells (ECs) build blood vessels and regulate their plasticity in coordination with
neurons. Likewise, neurons construct nerves and regulate their circuits in coordination with …