Radiotherapy has been used for more than a hundred years to cure or locally control tumors.
Regression of tumors outside of the irradiated field was occasionally observed and is known …

Radiotherapy—despite being a local therapy that meanwhile is characterized by an
impressively high degree of spatial accuracy—can stimulate systemic phenomena which …

Radiotherapy (RT) is used routinely as a standard treatment for more than 50% of patients
with malignant tumors. The abscopal effect induced by local RT, which is considered as a …

The abscopal effect is a systemic immune response mediated by the effects of radiation on
the immune system. This effect has been observed in a number of cancer types in addition to …

The concept of utilizing localized radiation therapy to elicit out-of-target tumor responses—
the abscopal effect—was proposed over 50 years ago (1, 2). Over the past decades, the …

The combination of radiation and immunotherapy is currently an exciting avenue of pre-
clinical and clinical investigation. The synergy between these two treatment modalities has …

The abscopal effect is mediated by a systemic anti-tumor immune response and reflects the
regression of non-irradiated metastatic lesions at a distance from the primary site of …

Radiotherapy has been used for more than a hundred years as a local tumor treatment. The
occurrence of systemic antitumor effects manifesting as regression of tumors outside of the …

More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression
of metastatic cancer at distant sites that are not irradiated was described and called the …

Abscopal effect is an interesting phenomenon in radiobiology that causes activation of
immune system against cancer cells. Traditionally, this phenomenon was known as a …