Probing Cell‐Surface Interactions in Fungal Cell Walls by High‐Resolution 1H‐Detected Solid‐State NMR Spectroscopy
A Safeer, F Kleijburg, S Bahri… - … A European Journal, 2023 - Wiley Online Library
Solid‐state NMR (ssNMR) spectroscopy facilitates the non‐destructive characterization of
structurally heterogeneous biomolecules in their native setting, for example, comprising …
structurally heterogeneous biomolecules in their native setting, for example, comprising …
Molecular architecture of fungal cell walls revealed by solid-state NMR
The high mortality of invasive fungal infections, and the limited number and inefficacy of
antifungals necessitate the development of new agents with novel mechanisms and targets …
antifungals necessitate the development of new agents with novel mechanisms and targets …
Solid-state NMR analysis of unlabeled fungal cell walls from Aspergillus and Candida species
LD Fernando, MCD Widanage, SC Shekar… - Journal of Structural …, 2022 - Elsevier
Fungal infections cause high mortality in immunocompromised individuals, which has
emerged as a significant threat to human health. The efforts devoted to the development of …
emerged as a significant threat to human health. The efforts devoted to the development of …
[HTML][HTML] Characterization of the cell wall of a mushroom forming fungus at atomic resolution using solid-state NMR spectroscopy
HL Ehren, FVW Appels, K Houben, MAM Renault… - The Cell Surface, 2020 - Elsevier
Cell walls are essential in the interaction of fungi with the (a) biotic environment and are also
key to hyphal morphogenesis and mechanical strength. Here, we used solid-state NMR …
key to hyphal morphogenesis and mechanical strength. Here, we used solid-state NMR …
Polysaccharide assemblies in fungal and plant cell walls explored by solid-state NMR
Structural analysis of macromolecular complexes within their natural cellular environment
presents a significant challenge. Recent applications of solid-state NMR (ssNMR) …
presents a significant challenge. Recent applications of solid-state NMR (ssNMR) …
A molecular vision of fungal cell wall organization by functional genomics and solid-state NMR
A Chakraborty, LD Fernando, W Fang… - Nature …, 2021 - nature.com
Vast efforts have been devoted to the development of antifungal drugs targeting the cell wall,
but the supramolecular architecture of this carbohydrate-rich composite remains …
but the supramolecular architecture of this carbohydrate-rich composite remains …
Solid-state NMR of plant and fungal cell walls: a critical review
The cell walls of plants and microbes are a central source for bio-renewable energy and the
major targets of antibiotics and antifungal agents. It is highly challenging to determine the …
major targets of antibiotics and antifungal agents. It is highly challenging to determine the …
[PDF][PDF] Solid-state NMR and DNP Investigations of Carbohydrates andCell-wall Biomaterials
The cell walls in plants and microbes serve as a central source for bio-renewable energy
and biomaterials, as well as the target for novel antibiotics and antifungals. They are …
and biomaterials, as well as the target for novel antibiotics and antifungals. They are …
Solid-state NMR molecular snapshots of Aspergillus fumigatus cell wall architecture during a conidial morphotype transition
G Lamon, A Lends, I Valsecchi… - Proceedings of the …, 2023 - National Acad Sciences
While establishing an invasive infection, the dormant conidia of Aspergillus fumigatus transit
through swollen and germinating stages, to form hyphae. During this morphotype transition …
through swollen and germinating stages, to form hyphae. During this morphotype transition …
Atomic force microscopy of fungal cell walls: an update
YF Dufrêne - Yeast, 2010 - Wiley Online Library
Although the chemical composition of many fungal cell walls is known, the spatial
organization and interactions of the individual macromolecules remain mysterious. In this …
organization and interactions of the individual macromolecules remain mysterious. In this …
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