Direct communication between cells, mediated by gap junctions, is nowadays considered as
an indispensable mechanism in the maintenance of cellular homeostasis. In fact, gap …

Connexins, a family of transmembrane proteins, are components of both gap junction
channels and hemichannels, which mediate the exchange of ions and small molecules …

Gap junctions are intercellular plasma membrane domains enriched in channels that allow
direct exchange of ions and small molecules between adjacent cells. Gap junction channels …

Gap junctions comprise arrays of intercellular channels formed by connexin proteins and
provide for the direct communication between adjacent cells. This type of intercellular …

Importance of the field: Connexins (Cxs) and gap junctional intercellular communications
(GJICs) play roles in cancer development, growth and metastasis. Experimental studies …

Cellular communication mediated by gap junction channels and hemichannels, both
composed of connexin proteins, constitutes two acknowledged regulatory platforms in the …

Gap junctions, intercellular channels structured by the connexin protein family, have been
implicated in the control of cell homeostasis, proliferation, differentiation and death. A loss of …

Connexins have been known to be the protein building blocks of gap junctions and mediate
cell–cell communication. In contrast to the conventional dogma, recent evidence suggests …

Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …

Cancer was one of the first pathologies to be associated with gap-junction defect. Despite
the evidence accumulated over the last 40-year period, the molecular involvement of gap …