Is there a role for biomarkers in thoracic aortic aneurysm disease?

D Balmforth, A Harky, B Adams, J Yap… - General thoracic and …, 2019 - Springer
Thoracic aortic aneurysm (TAA) represents a major cause of mortality and morbidity in
Western countries. The natural history of TAA is indolent, with patients usually being …

[HTML][HTML] Plasma biomarkers for distinguishing etiologic subtypes of thoracic aortic aneurysm disease

JS Ikonomidis, CR Ivey, JB Wheeler… - The Journal of thoracic …, 2013 - Elsevier
BACKGROUND: Thoracic aortic aneurysms (TAAs) develop through an asymptomatic
process resulting in gross dilation that progresses to rupture if left undetected and untreated …

Biomarkers in TAA—the holy grail

GHW van Bogerijen, JL Tolenaar, V Grassi… - Progress in …, 2013 - Elsevier
Thoracic aortic aneurysm (TAA) is a silent disease, often discovered at a time point that
dramatic complications, as rupture and dissection, occur. For the detection of asymptomatic …

Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights

A Martin‐Blazquez, A Heredero… - The Journal of …, 2021 - Wiley Online Library
Thoracic aortic aneurysm (TAA) develops silently and asymptomatically and is a major
cause of mortality. TAA prevalence is greatly underestimated, it is usually diagnosed …

Gene expression signature in peripheral blood detects thoracic aortic aneurysm

Y Wang, CC Barbacioru, D Shiffman… - PloS one, 2007 - journals.plos.org
Background Thoracic aortic aneurysm (TAA) is usually asymptomatic and associated with
high mortality. Adverse clinical outcome of TAA is preventable by elective surgical repair; …

Targeted proteomic analysis of patients with ascending thoracic aortic aneurysm

A Daskalopoulou, SG Giotaki, K Toli, A Minia, V Pliaka… - Biomedicines, 2023 - mdpi.com
Background: There is a need for clinical markers to aid in the detection of individuals at risk
of harboring an ascending thoracic aneurysm (ATAA) or developing one in the future …

Biological features of thoracic aortic diseases. Where are we now, where are we heading to: established and emerging biomarkers and molecular pathways

A Parolari, E Tremoli, P Songia, A Pilozzi… - European Journal of …, 2013 - academic.oup.com
Thoracic aortic aneurysms (TAAs) and aortic dissections (ADs) are among the main causes
of mortality and morbidity in Western countries. For this reason, the diagnosis, prevention …

Update on the molecular landscape of thoracic aortic aneurysmal disease

I Luyckx, IV Callejon, L Buccioli… - Current Opinion in …, 2022 - journals.lww.com
Thoracic aortic aneurysms (TAAs) are a pathological widening of the aorta in the thorax.
TAAs, which are clinically silent, are caused by vascular wall weakness predisposing …

Tracking an elusive killer: state of the art of molecular-genetic knowledge and laboratory role in diagnosis and risk stratification of thoracic aortic aneurysm and …

R De Cario, M Giannini, G Cassioli, A Kura, AM Gori… - Diagnostics, 2022 - mdpi.com
The main challenge in diagnosing and managing thoracic aortic aneurysm and dissection
(TAA/D) is represented by the early detection of a disease that is both deadly and “elusive” …

[HTML][HTML] The genetic basis of thoracic aortic disease: The future of aneurysm classification?

MY Salmasi, S Alwis, S Cyclewala, OA Jarral… - Hellenic Journal of …, 2023 - Elsevier
The expansion in the repertoire of genes linked to thoracic aortic aneurysms (TAA) has
revolutionised our understanding of the disease process. The clinical benefits of such …