Remodeling of the microenvironment by tumor cells can activate pathways that favor cancer
growth. Molecular delineation and targeting of such malignant-cell nonautonomous …

Disrupting the protective signals provided by the bone marrow microenvironment will be
critical for more effective combination drug therapies for acute myeloid leukemia (AML) …

IDO1 oxidizes tryptophan (TRP) to generate kynurenine (KYN), the substrate for 1-carbon
and NAD metabolism, and is implicated in pro-cancer pathophysiology and infection …

Bone metastases remain a serious health concern because of limited therapeutic options.
Here, we report that crosstalk between ROR1–HER3 and the Hippo–YAP pathway promotes …

Simple Summary There is clear evidence that inflammation can contribute to the
development of cancers, but the underlying mechanisms are not fully understood. This …

Chondrosarcomas represent the second most common primary bone malignancy. Despite
the vulnerability of chondrosarcoma cells to nicotinamide adenine dinucleotide (NAD+) …

Acute myeloid leukemia (AML) is characterized by a high relapse rate and dismal long-term
overall survival which is related to persistence of leukemia-initiating cells in their niche …

Metabolites of tryptophan degradation are known to alter mood. Their effects have only been
superficially examined in the context of pancreatic cancer. Herein, we study the role of …

There has been considerable scientific effort dedicated to understanding the biologic
consequence and therapeutic implications of aberrant tryptophan metabolism in brain …

Inhibition of NK and effector T-cell functions and activation of regulatory cell populations are
the main immunosuppressive effects of indoleamine-2, 3-dioxygenase1 (IDO1). By …