We studied the effect of lung-specific IL-4 expression on the T cell response during primary
and secondary heterologous infection with influenza virus by using transgenic mice that …

Currently, our understanding of mechanisms underlying cell-mediated immunity and
particularly of mechanisms that promote robust T cell memory to respiratory viruses is …

The factors that regulate the contraction of the CD8 T cell response and the magnitude of the
memory cell population against localized mucosal infections such as influenza are important …

Two different subsets of T cells, Th1 and Th2 cells, have been demonstrated to secrete
different profiles of cytokines and to influence various infections in different ways. Whereas …

T lymphocytes play a primary role in recovery from viral infections and in antiviral immunity.
Although viral-specific CD8+ and CD4+ T cells have been shown to be able to lyse virally …

Analysis of the respiratory tract before and after primary influenza virus infection revealed a
virus-induced preferential accumulation of a CD8+ T-cell population that coexpresses …

ABSTRACT Interleukin-1α (IL-1α) and IL-1β are proinflammatory cytokines, which induce a
plethora of genes and activities by binding to the type 1 IL-1 receptor (IL-1R1). We have …

ABSTRACT Interleukin-10 (IL-10) is an important anti-inflammatory molecule that can cause
immunosuppression and long-term pathogen persistence during chronic infection of mice …

The potent innate cytokines IL‐12 and IL‐18 are considered to be important antigen‐
independent mediators of IFN‐γ production by NK cells and T lymphocytes. The present …

Memory CD4 T cells specific for influenza virus are generated from natural infection and
vaccination, persist long-term, and recognize determinants in seasonal and pandemic …