To appreciate the importance of the transporters in drug delivery and excretion, an
understanding of the molecular and functional characteristics of drug transporters, such as …

Membrane transporters are integral membrane proteins typically having 12 transmembrane
domains. Most of the SLC family transporters consist of 300–800 amino acid residues with a …

It has long been believed that most of drugs are absorbed by passive diffusion mechanism.
However, some drugs have been suggested to be absorbed by specialized transporters …

Tissues such as liver, kidney, brain and intestine expresses membrane transporters which
play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of …

The aim of this study was to investigate the gene and protein expression profiles of important
drug-transporting proteins in human cell lines commonly used for studies of drug transport …

It is increasingly recognized that various transporter proteins are expressed throughout the
body and determine absorption, tissue distribution, biliary and renal elimination of …

Cumulative studies have revealed the importance of transporters in drug disposition in the
body. Recently, organic anion transporters such as organic anion transporting polypeptides …

The absorption of drugs from the gastrointestinal tract is one of the important determinants
for oral bioavailability. Development of in vitro experimental techniques such as isolated …

Proteins that are capable to transport molecules across membranes are fundamental for the
accurate functioning of the body. Many diseases have their cause in a dysfunction of a …

Pharmaceutical scientists increasingly utilize transporters for drug delivery and targeting.
The biological barriers to drug delivery can basically be divided into epithelial, endothelial …