Sepsis is a common condition that is associated with significant morbidity, mortality and
health-care cost. Pulmonary and non-pulmonary sepsis are common causes of the acute …

Platelet activation plays an important role in the development of sepsis. During sepsis,
platelet activation leads to endothelial cell injury and promotes neutrophil extracellular trap …

Background: The acute respiratory distress syndrome (ARDS) is a life-threating disorder that
contributes significantly to critical illness. No specific pharmacological interventions directed …

Rationale Platelets play an active role in the pathogenesis of acute respiratory distress
syndrome (ARDS). Animal and observational studies have shown aspirin's antiplatelet and …

Background Antiplatelet therapy may attenuate the undesirable effects of platelets on the
inflammatory cascades in critical illness. The objective of this study was to evaluate the …

Platelet activation has been implicated in microvascular thrombosis and organ failure in
critically ill patients. In the first part the present paper summarises important data on the role …

Acute lung injury (ALI) is a common syndrome associated with a high mortality rate. Better
understanding of the pathophysiology of acute lung injury and progress in supportive care …

Purpose Abnormal platelet activation plays an important role in the development of sepsis.
The effect of antiplatelet drugs on the outcome of patients with sepsis remains unclear. This …

Beyond their important role in hemostasis, platelets play a crucial role in inflammatory
diseases. This becomes apparent during sepsis, where platelet count and activation …

Conclusions Platelets play a complex role in sepsis; they are able to modulate not only their
own function but also that of cells around them. Further study is needed to better define the …