Neurodevelopmental disorders and environmental toxicants: epigenetics as an underlying mechanism

NQV Tran, K Miyake - International journal of genomics, 2017 - Wiley Online Library
The increasing prevalence of neurodevelopmental disorders, especially autism spectrum
disorders (ASD) and attention deficit hyperactivity disorder (ADHD), calls for more research …

Multifactorial origin of neurodevelopmental disorders: approaches to understanding complex etiologies

A De Felice, L Ricceri, A Venerosi, F Chiarotti… - Toxics, 2015 - mdpi.com
A significant body of evidence supports the multifactorial etiology of neurodevelopmental
disorders (NDDs) affecting children. The present review focuses on early exposure to …

Epigenetic and neurological impairments associated with early life exposure to persistent organic pollutants

N Grova, H Schroeder, JL Olivier… - International journal of …, 2019 - Wiley Online Library
The incidence of neurodevelopmental and neurodegenerative diseases worldwide has
dramatically increased over the last decades. Although the aetiology remains uncertain …

DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders?

KP Keil, PJ Lein - Environmental epigenetics, 2016 - academic.oup.com
There is now compelling evidence that gene by environment interactions are important in
the etiology of autism spectrum disorders (ASDs). However, the mechanisms by which …

[HTML][HTML] Environmental epigenetic changes, as risk factors for the development of diseases in children: a systematic review

I Alvarado-Cruz, JA Alegría-Torres… - Annals of global …, 2018 - ncbi.nlm.nih.gov
Background: Children are susceptible to environmental contaminants and are at risk of
developing diseases, more so if the exposure begins at an early age. Epidemiological …

Epigenetics at the interface of genetics and environmental factors in autism

JM LaSalle, RO Vallero, MM Mitchell - Environmental Epigenomics in …, 2013 - Springer
Autism spectrum disorders have a complex etiology, suggesting that multiple genetic and
environmental factors play a role in their etiology. The apparent rise in the prevalence of …

Environmental exposures and gene regulation in disease etiology

TM Edwards, JP Myers - Environmental health perspectives, 2007 - ehp.niehs.nih.gov
Objective Health or disease is shaped for all individuals by interactions between their genes
and environment. Exactly how the environment changes gene expression and how this can …

The epigenetic link between prenatal adverse environments and neurodevelopmental disorders

M Kundakovic, I Jaric - Genes, 2017 - mdpi.com
Prenatal adverse environments, such as maternal stress, toxicological exposures, and viral
infections, can disrupt normal brain development and contribute to neurodevelopmental …

Environmental toxicology: Sensitive periods of development and neurodevelopmental disorders

DB Heyer, RM Meredith - Neurotoxicology, 2017 - Elsevier
Abstract Development of the mammalian central nervous system is a complex process
whose disruption may have severe and long-lasting consequences upon brain structure and …

A review on neuroimaging studies of genetic and environmental influences on early brain development

W Gao, K Grewen, RC Knickmeyer, A Qiu, A Salzwedel… - Neuroimage, 2019 - Elsevier
The past decades witnessed a surge of interest in neuroimaging study of normal and
abnormal early brain development. Structural and functional studies of normal early brain …