The emergence and evolution of metabolic pathways represented a crucial step in
molecular and cellular evolution. In fact, the exhaustion of the prebiotic supply of amino …

The emergence and evolution of metabolic pathways represented a crucial step in
molecular and cellular evolution. In fact, the exhaustion of the prebiotic supply of amino …

The emergence and evolution of metabolic pathways represented a crucial step in
molecular and cellular evolution, allowing primitive organisms to become less dependent on …

The heterotrophic theory of the origin of life is the only proposal available with experimental
support. This comes from the ease of prebiotic synthesis under strongly reducing conditions …

The phylogenetic distribution of divergently related protein families into the three domains of
life (archaea, bacteria and eukaryotes) can signify the presence or absence of entire cellular …

Background It is generally assumed that primordial cells had small genomes with simple
genes coding for enzymes able to react with a wide range of chemically related substrates …

Until recently, prebiotic precursors to metabolic pathways were not known. In parallel,
chemistry achieved the synthesis of amino acids and nucleotides only in reaction sequences …

Prebiotic chemistry aims to explain how the biochemistry of life as we know it came to be.
Most efforts in this area have focused on provisioning compounds of importance to life by …

Since the last decade of the twentieth century, systems biology has gained the ability to
study the structure and function of genome-scale metabolic networks. These are systems of …

It is generally assumed that the complex map of metabolism is a result of natural selection
working at the molecular level. However, natural selection can only work on entities that …