Background—The Scandinavian Simvastatin Survival Study (4S) randomized 4444 patients
with coronary heart disease (CHD) and serum cholesterol 5.5 to 8.0 mmol/L (213 to 310 …

The Scandinavian Simvastatin Survival Study (4S) was designed to evaluate the effects of
cholesterol reduction with simvastatin on mortality and morbidity in patients with coronary …

Drug therapy for hypercholesterolaemia has remained controversial mainly because of
insufficient clinical trial evidence for improved survival. The present trial was designed to …

Background In several angiographic trials, HMG-CoA reductase inhibitors have shown a
beneficial effect on the progression of coronary artery disease. Using 20 mg simvastatin …

We report the results of a randomized single-centre study designed to assess the effects of
simvastatin on blood lipids, blood biochemistry, haematology and other measures of safety …

The possibility that effective lipid reduction could have beneficial effects on atherosclerotic
diseases other than coronary artery disease has received little attention. For example …

The Scandinavian Simvastatin Survival Study (4S) and other randomized clinical trials have
demonstrated that cholesterol-lowering treatment with statins improves prognosis in patients …

Drug therapy for hypercholesterolaemia has remained controversial mainly because of
insufficient clinical trial evidence for improved survival. The present trial was designed to …

Background: Long-term safety is an important consideration in the selection and use of
drugs, such as lipid-lowering agents, that are prescribed to reduce the risk of clinical events …

Background—Patients with low HDL cholesterol (HDL-C) and elevated triglyceride had an
increased risk for coronary heart disease (CHD) events and received the greatest benefit …