Background Ischemic stroke is a serious cerebrovascular disease with high morbidity and
disability. Zinc accumulation has been shown to play a vital role in neuronal death and …

Intracellular zinc accumulation has been shown to be associated with neuronal death after
cerebral ischemia. However, the mechanism of zinc accumulation leading to neuronal death …

Background and Purpose—Zinc has been reported to possess both neurotoxic and
neuroprotective capabilities. The effects of elevated intracellular zinc accumulation following …

Background and Purpose—Although intracellular zinc accumulation has been shown to
contribute to neuronal death after cerebral ischemia, the mechanism by which zinc keeps on …

Aim Pathological release of excess zinc ions has been implicated in ischemic brain cell
death. However, the underlying mechanisms remain to be elucidated. In stroke, ischemia …

Zinc is the second most abundant metal in human and serves as an essential trace element
in the body. During the past decades, zinc has been found to play important roles in central …

Zinc is prevalent in the mammalian central nervous system and its role in ischemic brain
injury is still controversial. In the present study, the effect of zinc in ischemic brain injury was …

Zinc ions are stored in synaptic vesicles and cerebral ischemia triggers their release from
the terminals of neurons. Zinc accumulation in neurons has been shown to play an important …

Objective Brain-derived neurotrophic factor (BDNF) plays a key role in the pathophysiology
process and therapy of spinal cord injury (SCI). Accordingly, zinc regulates the expression of …

Ischemic stroke is one of the most pervasive life-threatening neurological conditions for
which there currently exists limited therapeutic intervention beyond prevention. As calcium …