LncRNA TSIX aggravates spinal cord injury by regulating the PI3K/AKT pathway via the miR‐532‐3p/DDOST axis

J Dong, Z Wei, Z Zhu - Journal of Biochemical and Molecular …, 2023 - Wiley Online Library
Abstract Long noncoding RNA (lncRNA)‐X‐inactive‐specific transcript (TSIX) expression is
upregulated in spinal cord tissues following spinal cord injury (SCI). However, the role of …

LncRNA TSIX knockdown restores spinal cord injury repair through miR-30a/SOCS3 axis

Z Pan, K Huang, N Li, P Duan, J Huang… - Biotechnology and …, 2023 - Taylor & Francis
Spinal cord injury (SCI) is a serious injury to the central nervous system. Previous studies
have discovered that the development of SCI is associated with gene expression. The …

lncRNA XIST inhibition promotes M2 polarization of microglial and aggravates the spinal cord injury via regulating miR-124–3p/IRF1 axis

J Yang, Z Gong, J Dong, H Bi, B Wang, K Du, C Zhang… - Heliyon, 2023 - cell.com
Background Spinal cord injury (SCI) has a high disability rate and mortality rate. Recently,
LncRNA XIST has been found to be involved in the regulation of inflammatory responses …

Long noncoding RNA XIST knockdown relieves the injury of microglia cells after spinal cord injury by sponging miR-219-5p

X Zhong, Y Bao, Q Wu, X Xi, W Zhu, S Chen, J Liao - Open Medicine, 2021 - degruyter.com
Long noncoding RNAs have been demonstrated to play crucial roles in the pathogenesis of
spinal cord injury (SCI). In this study, we aimed to explore the roles and underlying …

Long coding RNA XIST contributes to neuronal apoptosis through the downregulation of AKT phosphorylation and is negatively regulated by miR-494 in rat spinal …

S Gu, R Xie, X Liu, J Shou, W Gu, X Che - International journal of …, 2017 - mdpi.com
Recent evidence has suggested that long non-coding RNAs (lncRNAs) may play a
significant role in the pathogenesis of several neurological diseases, including spinal cord …

[HTML][HTML] Knockdown of long noncoding RNA XIST mitigates the apoptosis and inflammatory injury of microglia cells after spinal cord injury through miR-27a/Smurf1 …

Q Zhao, F Lu, Q Su, Z Liu, X Xia, Z Yan, F Zhou… - Neuroscience letters, 2020 - Elsevier
Spinal cord injury (SCI) is a devastating neuropathological condition. Long noncoding RNA
X-inactive specific transcript (XIST) is an acknowledged cancer-related gene and …

[PDF][PDF] LncRNA ZNF667-AS1 inhibits inflammatory response and promotes recovery of spinal cord injury via suppressing JAK-STAT pathway

JW Li, Y Kuang, L Chen… - Eur Rev Med Pharmacol …, 2018 - europeanreview.org
OBJECTIVE: The aim of this study was to explore the role of lncRNA ZNF667-AS1 in the
recovery of spinal cord injury (SCI), and to investigate its underlying mechanism …

[HTML][HTML] Dysregulation in the expression of (lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283) in spinal cord injury

SMM Salah, M Matboli, HET Nasser, IA Abdelnaiem… - Genomics, 2020 - Elsevier
Aim The objective of this study is to examine the alterations in the levels of expression of
serum lncRNA-TSIX, TP53INP2 mRNA, miRNA-1283 in spinal cord injured (SCI) patients …

Long non-coding RNA DANCR increases spinal cord neuron apoptosis and inflammation of spinal cord injury by mediating the microRNA-146a-5p/MAPK6 axis

L Shi, L Duan, D Duan, H Xu, X Li, W Zhao - European Spine Journal, 2024 - Springer
Objective This research was to unravel the impact of the lncRNA differentiation antagonizing
non-protein coding RNA (DANCR)/microRNA (miR)-146a-5p/mitogen-activated protein …

Stat3-induced lncRNA Kcnq1ot1 regulates the apoptosis of neuronal cells in spinal cord injury

W Jiang, S Zhang, Q Lai, Y Fang, M Wang - Journal of Molecular …, 2022 - Springer
Emerging evidence validates the vital roles of long noncoding RNAs (lncRNAs) in spinal
cord injury (SCI), which attracts great attention. In the present study, our study investigated …