Aging results in remodeling of T cell immunity and is associated with poor clinical outcomes
in age-related diseases such as cancer. Among the hallmarks of aging, changes in host and …

It is now clear that access to specific metabolic programmes controls the survival and
function of various immune cell populations, including T cells. Efficient naïve and memory T …

Beginning with the sixth decade of life, the human immune system undergoes dramatic
aging-related changes, which continuously progress to a state of immunosenescence. The …

The aging immune system is unable to optimally respond to pathogens and generate long-
term immunological memory against encountered antigens. Amongst the immune …

Cancer immunotherapy is an increasingly successful strategy for the treatment of patients
who have advanced or conventional therapy-resistant cancers. T cells are key mediators of …

Average age and obesity prevalence are increasing globally. Both aging and obesity are
characterized by profound systemic metabolic and immunologic changes and are cancer …

T cells have a pivotal protective role in defense against infection and cancer but also are
instrumental in the development of many autoimmune diseases. The regulation of nutrient …

T cell-mediated immune responses are compromised in aged individuals, leading to
increased morbidity and reduced response to vaccination. While cellular metabolism tightly …

Metabolism drives function, on both an organismal and a cellular level. In T cell biology,
metabolic remodeling is intrinsically linked to cellular development, activation, function …

Productive T cell responses to infection and cancer rely on coordinated metabolic
reprogramming and epigenetic remodeling among the immune cells. In particular, T cell …